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Literature summary for 2.7.11.26 extracted from
- A novel tau-tubulin kinase from bovine brain (1995), FEBS Lett., 372, 59-64.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| tubulin | - |
Bos taurus |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | brain pathology in investigation of Alzheimers's disease, human tau phosphorylated by the kinase carries an epitope of the paired helical filaments that accumulate in the brain | Bos taurus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 32000 | - |
gel filtration, SDS-PAGE | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + protein tau | Bos taurus | - |
ADP + protein tau phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
bovine | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 3 isoenzymes, tau protein kinase I and II and tau-tubulin kinase | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.01325 | - |
activity towards tubulin | Bos taurus |
| 0.01665 | - |
activity towards tau | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + alpha-casein | - |
Bos taurus | ADP + alpha-casein phosphate | - |
? | |
| ATP + dephospho-beta-tubulin | isoenzyme tau-tubulin kinase | Bos taurus | ADP + beta-tubulin phosphate | - |
? | |
| ATP + KAUSSPTVSRKTD | synthetic peptide p25/F3 | Bos taurus | ADP + KAUSSPTVSRKTD phosphate | - |
? | |
| ATP + MADSRPKPANKTPPK | synthetic peptide F5f | Bos taurus | ADP + MADSRPKPANKTPPK phosphate | - |
? | |
| ATP + MAP2 | - |
Bos taurus | ADP + MAP2 phosphate | - |
? | |
| ATP + MARSRPK | synthetic peptide F5h | Bos taurus | ADP + MARSRPK phosphate | - |
? | |
| ATP + PANKTPPKSPGEPAKDPAAK | synthetic peptide p25/F5a | Bos taurus | ADP + PANKTPPKSPGEPAKDPAAK phosphate | - |
? | |
| ATP + protein tau | - |
Bos taurus | ADP + protein tau phosphate | - |
? | |
| ATP + protein tau | phosphorylates tau and forms paired helical filament epitopes, tau/K1, K2, K3 and tau/4 repeat | Bos taurus | ADP + protein tau phosphate | - |
? | |
| ATP + RADSRPK | synthetic peptide F5g | Bos taurus | ADP + RADSRPK phosphate | - |
? | |
| ATP + RKRSRAE | synthetic peptide 8659 | Bos taurus | ADP + RKRSRAE phosphate | - |
? | |
| ATP + RKRSRKE | synthetic peptide 8655 | Bos taurus | ADP + RKRSRKE phosphate | - |
? | |
| ATP + RRREEETEEE | synthetic peptide CKII substrate | Bos taurus | ADP + RRREEETEEE phosphate | - |
? | |
| additional information | novel isoenzyme, distinct from TPKI, TPKII CKI and CKII, no activity toward beta-casein and neurofilament, no reaction with synthetic peptides F5a PANKTPPKSPGEPAKDPAAK, F5n MADSRPK, F5d MADSRKPAN, F5e MADSRPAE and 8656 RKRARKE, only weak activity with histones H1, H2a and H2b as substrates | Bos taurus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| tau-protein kinase I | - |
Bos taurus |
| tau-protein kinase II | - |
Bos taurus |
| tau-tubulin kinase | - |
Bos taurus |
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