Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.25 extracted from

  • Zhou, X.; Ma, Y.; Sugiura, R.; Kobayashi, D.; Suzuki, M.; Deng, L.; Kuno, T.
    MAP kinase kinase kinase (MAPKKK)-dependent and -independent activation of Sty1 stress MAPK in fission yeast (2010), J. Biol. Chem., 285, 32818-32823.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.25

Protein Variants

Protein Variants Comment Organism
additional information generation of DELTAwis4/wak1/wik1 single and DELTAwis4/wak1/wik1/DELTAwin1 double knockout mutants Schizosaccharomyces pombe

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Atf1 Schizosaccharomyces pombe MAPK kinase Atf1 activation ADP + phosphorylated Atf1
-
 ?
ATP + Atf1 Schizosaccharomyces pombe 972 MAPK kinase Atf1 activation ADP + phosphorylated Atf1
-
 ?
ATP + Sty1 Schizosaccharomyces pombe MAPK kinase Sty1 activation ADP + phosphorylated Sty1
-
 ?
ATP + Sty1 Schizosaccharomyces pombe 972 MAPK kinase Sty1 activation ADP + phosphorylated Sty1
-
 ?

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe O14299 genes wis4, wak1, and wik1, strain 972
-
Schizosaccharomyces pombe O74304 gene win1, strain 972
-
Schizosaccharomyces pombe 972 O14299 genes wis4, wak1, and wik1, strain 972
-
Schizosaccharomyces pombe 972 O74304 gene win1, strain 972
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Atf1 MAPK kinase Atf1 activation Schizosaccharomyces pombe ADP + phosphorylated Atf1
-
 ?
ATP + Atf1 MAPK kinase Atf1 activation Schizosaccharomyces pombe 972 ADP + phosphorylated Atf1
-
 ?
ATP + Sty1 MAPK kinase Sty1 activation Schizosaccharomyces pombe ADP + phosphorylated Sty1
-
 ?
ATP + Sty1 MAPK kinase Sty1 activation Schizosaccharomyces pombe 972 ADP + phosphorylated Sty1
-
 ?

Synonyms

Synonyms Comment Organism
MAP kinase kinase kinase
-
 Schizosaccharomyces pombe
MAPKKK
-
 Schizosaccharomyces pombe
Wak1
-
 Schizosaccharomyces pombe
Wik1
-
 Schizosaccharomyces pombe
Win1
-
 Schizosaccharomyces pombe
Wis4
-
 Schizosaccharomyces pombe

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Schizosaccharomyces pombe

General Information

General Information Comment Organism
malfunction in cadmium and low glucose medium, Atf1 activation is observed even in the absence of all four fission yeast MAPK kinase kinases (MAPKKKs), whereas in osmotic stress, Atf1 activation is abolished Schizosaccharomyces pombe
metabolism the four MAPKKKs in fission yeast are involved in MAPK activation, e.g. Atf1 or Sty1, in osmotic stress. Osmotic stress, e.g. by KCl, likely mediates the MAPK activation via MAPKKKs, whereas a cadmium or low-glucose condition activates the MAPK in a MAPKKK-independent manner. Protein-tyrosine phosphatases Pyp1 and Pyp2 are negative regulators of the Sty1 MAPK cascade Schizosaccharomyces pombe