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Literature summary for 2.7.11.25 extracted from

  • Li, L.; Ye, C.; Zhao, R.; Li, X.; Liu, W.Z.; Wu, F.; Yan, J.; Jiang, Y.Q.; Yang, B.
    Mitogen-activated protein kinase kinase kinase (MAPKKK) 4 from rapeseed (Brassica napus L.) is a novel member inducing ROS accumulation and cell death (2015), Biochem. Biophys. Res. Commun., 467, 792-797.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
gene MAPKKK4.1, DNA and amino acid sequence determination and analysis, sequence comparison, phylogenetic tree, quantitative RT-PCR expression analysis, recombinant expression in transgenic Nicotiana benthamiana leaves under the driving of CaMV35S promoter, recombinant coexpression with substrate proteins MKK3 and MKK6 in Saccharomyces cerevisiae strain AH109 cells Brassica napus
gene MAPKKK4.2, DNA and amino acid sequence determination and analysis, sequence comparison, phylogenetic tree, quantitative RT-PCR expression analysis, recombinant expression in transgenic Nicotiana benthamiana leaves under the driving of CaMV35S promoter, recombinant coexpression with substrate proteins MKK3 and MKK6 in Saccharomyces cerevisiae strain AH109 cells Brassica napus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Brassica napus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + MKK3 Brassica napus substrate Brassica napus MAPK kinase 3 ADP + phosphorylated MKK3
-
 ?
ATP + MKK6 Brassica napus substrate Brassica napus MAPK kinase 6 ADP + phosphorylated MKK6
-
 ?

Organism

Organism UniProt Comment Textmining
Brassica napus A0A0U1XFB1 gene MAPKKK4.2
-
Brassica napus A0A0U1XFE3 gene MAPKKK4.1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + MKK3 substrate Brassica napus MAPK kinase 3 Brassica napus ADP + phosphorylated MKK3
-
 ?
ATP + MKK6 substrate Brassica napus MAPK kinase 6 Brassica napus ADP + phosphorylated MKK6
-
 ?

Synonyms

Synonyms Comment Organism
BnaMAPKKK4.2
-
 Brassica napus
MAPKKK4
-
 Brassica napus
mitogen-activated protein kinase kinase kinase 4
-
 Brassica napus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Brassica napus

General Information

General Information Comment Organism
metabolism MAPKK kinase family enzymes play important roles in plant growth, development and immune responses. The two downstream kinases MKK3 and MKK6 act in the BnaMAPKKK4 signaling pathway Brassica napus
physiological function expression of MAPKKK4 elicits reactive oxgen species, ROS, i.e. H2O2 accumulation and cell death. Upregulation of enzyme MAPKKK4 leads to increased expression of ROS accumulation, cell death, and defense response related genes Brassica napus