Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.25 extracted from

  • Sun, W.; Wang, H.; Zhao, X.; Yu, Y.; Fan, Y.; Wang, H.; Wang, X.; Lu, X.; Zhang, G.; Fu, S.; Yang, J.
    Protein phosphatase 2A acts as a mitogen-activated protein kinase kinase kinase 3 (MEKK3) phosphatase to inhibit lysophosphatidic acid-induced IkappaB kinase beta /nuclear factor-kappaB activation (2010), J. Biol. Chem., 285, 21341-21348.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.25

Cloned(Commentary)

Cloned (Comment) Organism
subcloned into the HA-tagged mammalian expression vector pcDNA3.1 Homo sapiens

Protein Variants

Protein Variants Comment Organism
T516A/S520A MEKK3 with double alanine mutations can not bind the catalytic subunit of protein phosphatase 2a Homo sapiens
T516E/S520D double mutant, MEKK3 is phosphorylated at Thr-516 and Ser-520 within the kinase activation loop by protein phosphatase 2a Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Protein phosphatase 2A PP2A, dephosphorylates and inactivates MEKK3 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Homo sapiens
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q99759
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Homo sapiens ADP + a phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
MEKK3
-
 Homo sapiens
mitogen-activated protein kinase kinase kinase 3
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function MEKK3 is a central intermediate signaling component in lysophosphatidic acid-induced activation of the nuclear factor-kappa B Homo sapiens