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Literature summary for 2.7.11.25 extracted from

  • Mongan, M.; Tan, Z.; Chen, L.; Peng, Z.; Dietsch, M.; Su, B.; Leikauf, G.; Xia, Y.
    Mitogen-activated protein kinase kinase kinase 1 protects against nickel-induced acute lung injury (2008), Toxicol. Sci., 104, 405-411.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
MAP2K + ATP Mus musculus involved in reducing c-jun N-terminal kinase (JNK, MAPK8) activation and protecting the mice from nickel-induced acute lung injury MAP2K-phosphate + ADP
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
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wild type embryonic fibroblast and cells with a MAP3K deletion used for experiments
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Source Tissue

Source Tissue Comment Organism Textmining
cerebellum
-
Mus musculus
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fibroblast
-
Mus musculus
-
heart
-
Mus musculus
-
lung highly expressed Mus musculus
-
additional information not detected in kidney and liver Mus musculus
-
olfactory bulb highly expressed Mus musculus
-
skin highly expressed Mus musculus
-
spleen highly expressed Mus musculus
-
testis
-
Mus musculus
-
thymus highly expressed Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
MAP2K + ATP involved in reducing c-jun N-terminal kinase (JNK, MAPK8) activation and protecting the mice from nickel-induced acute lung injury Mus musculus MAP2K-phosphate + ADP
-
?

Synonyms

Synonyms Comment Organism
MAP3K
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Mus musculus
MAP3K1
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Mus musculus