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Literature summary for 2.7.11.25 extracted from
- A MAP kinase cascade required for regulation of development and secondary metabolism in Neurospora crassa (2008), Eukaryot. Cell, 7, 2113-22.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| MEK-1 + ATP | Neurospora crassa | essential step of the MAP-kinase cascade, activation of MEK-1 which is a MAPKK, essential role in vegetative hyphal growth, conidiation and protoperithecial development, as well as a more limited involvement in maintenance of cell wall integrity, not essential for the resistance to osmotic stress, negatively regulates tyrosinase expression | phosphorylated MEK-1 + ADP | - |
? |  |
| additional information | Neurospora crassa | involved in the regulation of development and secondary metabolism, deficiency mutant forms short aerial hyphae, show reduced formation of asexual macroconidia, and reduced growth | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Neurospora crassa | - |
strains ORS-SL6a and 74-OR23-IVA and deletion mutants | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| MEK-1 + ATP | essential step of the MAP-kinase cascade, activation of MEK-1 which is a MAPKK, essential role in vegetative hyphal growth, conidiation and protoperithecial development, as well as a more limited involvement in maintenance of cell wall integrity, not essential for the resistance to osmotic stress, negatively regulates tyrosinase expression | Neurospora crassa | phosphorylated MEK-1 + ADP | - |
? | |
| additional information | involved in the regulation of development and secondary metabolism, deficiency mutant forms short aerial hyphae, show reduced formation of asexual macroconidia, and reduced growth | Neurospora crassa | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MAPKKK | - |
Neurospora crassa |
| mik-1 | - |
Neurospora crassa |
| More | MAP kinase cascade is homologous to the Saccharomyces cerevisiae Slt2p pathway | Neurospora crassa |
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