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Literature summary for 2.7.11.25 extracted from

  • Winkel, A.; Stricker, S.; Tylzanowski, P.; Seiffart, V.; Mundlos, S.; Gross, G.; Hoffmann, A.
    Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling (2008), Cell. Signal., 20, 2134-2144.
    View publication on PubMed
Search for more literature for 2.7.11.25

Cloned(Commentary)

Cloned (Comment) Organism
TAK1 expression in HEK-293 cells, Ror2-Tak1 interaction analysis by expression in the yeast two-hybrid system Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Ror2 Mus musculus TGF-beta activated kinase 1, a MAPKKK, interacts with Ror2 and phosphorylates its intracellular carboxyterminal serine/thronine/proline-rich, STP, domain, Wnt-ligand binding differentially controls the Ror2/TAK1 interaction, Ror2 seems to act as a Wnt co-receptor enhancing Wnt-dependent canonical pathways while Tyr- and Ser/Thr-phosphorylation of Ror2 negatively controls the efficiency of these pathways, overview ADP + phospho-Ror2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q62073
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Ror2 TGF-beta activated kinase 1, a MAPKKK, interacts with Ror2 and phosphorylates its intracellular carboxyterminal serine/thronine/proline-rich, STP, domain, Wnt-ligand binding differentially controls the Ror2/TAK1 interaction, Ror2 seems to act as a Wnt co-receptor enhancing Wnt-dependent canonical pathways while Tyr- and Ser/Thr-phosphorylation of Ror2 negatively controls the efficiency of these pathways, overview Mus musculus ADP + phospho-Ror2
-
 ?
ATP + Ror2 TAK1 phosphorylates Ror2, a receptor tyrosine kinase, at multiple sites, activity of TAK1 with Ror2 phosphorylation site mutants, overview Mus musculus ADP + phospho-Ror2
-
 ?

Subunits

Subunits Comment Organism
More TAK1 domain structure, overview Mus musculus

Synonyms

Synonyms Comment Organism
MAP3K
-
 Mus musculus
TAK1
-
 Mus musculus
TGF-beta-activated kinase-1
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus