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Literature summary for 2.7.11.25 extracted from

  • Jonas, B.A.; Varlakhanova, N.; Hayakawa, F.; Goodson, M.; Privalsky, M.L.
    Response of SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) corepressors to mitogen-activated protein kinase kinase kinase cascades is determined by alternative mRNA splicing (2007), Mol. Endocrinol., 21, 1924-1939.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
additional information cells can customize their transcriptional response to MAPKKK cascade signaling by selective expression of the SMRT or N-CoR locus, by selective utilization of a specific corepressor splice variant, and by selective exploitation of specific tiers of the MAPK cascade synthetic construct

Cloned(Commentary)

Cloned (Comment) Organism
MEKK1 construct expressed using CV-1 cells synthetic construct

Organism

Organism UniProt Comment Textmining
synthetic construct
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + SMRT SMRT is regulated by MAPKKK cascades that induce its release from its receptor partners, its export from nucleus to cytoplasm, and derepression of target gene expression. SMRTalpha, SMRTtau, and SMRTsp2 splice variants are released from their nuclear receptor partners in response to MAPKKK activation, the SMRTsp18 variant, which resembles N-CoR in its overall molecular architecture, is relatively refractory to this kinase-induced release synthetic construct ADP + phosphorylated SMRT
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 ?
additional information N-CoR is refractory to MAPKKK signaling, alternative splicing of N-CoR has only minimal effects on the resistance of this corepressor to MAPKKK inhibition synthetic construct ?
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 ?

Synonyms

Synonyms Comment Organism
MAPK kinase kinase
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 synthetic construct
MAPKKK
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 synthetic construct
MEKK1
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 synthetic construct