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Literature summary for 2.7.11.25 extracted from

  • Shi, C.S.; Huang, N.N.; Harrison, K.; Han, S.B.; Kehrl, J.H.
    The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes (2006), Mol. Cell. Biol., 26, 6511-6521.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.25

Activating Compound

Activating Compound Comment Organism Structure
Wnt3a induces GCKR kinase activity. APC, Asef, and Rac are required for Wnt signaling to activate GCKR Mus musculus
Wnt3a induces GCKR kinase activity. APC, Asef, and Rac are required for Wnt signaling to activate GCKR Homo sapiens

Application

Application Comment Organism
medicine GCKR facilitates both canonical and noncanonical Wnt signaling in B lymphocytes Mus musculus
medicine GCKR facilitates both canonical and noncanonical Wnt signaling in B lymphocytes Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
into PCR3.1 vector and expressed in HEK-293 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information Gckr-/- cells, have a significant defect in Wnt-mediated JNK activation and in induction of beta-catenin compared to wild-type Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information sFRP-1 significantly impairs Wnt3a-conditioned-media-induced activation of GCKR Homo sapiens
additional information sFRP-1 significantly impairs Wnt3a-conditioned-media-induced activation of GCKR Mus musculus
shRNA silences GCKR expression Homo sapiens
shRNA silences GCKR expression Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-
cytoplasm
-
 Homo sapiens 5737
-
plasma membrane to a lesser degree Mus musculus 5886
-
plasma membrane to a lesser degree Homo sapiens 5886
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
 Mus musculus
-
B-lymphocyte
-
 Homo sapiens
-
BJAB cell
-
 Homo sapiens
-
HEK-293 cell
-
 Homo sapiens
-
RAJI cell
-
 Homo sapiens
-
WEHI-231 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GSK3beta regulates phosphorylation at serine 9 Mus musculus ADP + phosphorylated GSK3beta
-
 ?
ATP + GSK3beta regulates phosphorylation at serine 9 Homo sapiens ADP + phosphorylated GSK3beta
-
 ?
ATP + GSK3beta regulates phosphorylation at serine 9 Mus musculus C57BL/6 ADP + phosphorylated GSK3beta
-
 ?
ATP + JNK required for Wnt-mediated JNK activation in B cells Mus musculus ADP + phosphorylated JNK
-
 ?
ATP + JNK required for Wnt-mediated JNK activation in B cells Homo sapiens ADP + phosphorylated JNK
-
 ?
ATP + JNK required for Wnt-mediated JNK activation in B cells Mus musculus C57BL/6 ADP + phosphorylated JNK
-
 ?

Synonyms

Synonyms Comment Organism
GCKR
-
 Mus musculus
GCKR
-
 Homo sapiens
germinal center kinase-related enzyme
-
 Mus musculus
germinal center kinase-related enzyme
-
 Homo sapiens
mitogen-activated protein kinase kinase kinase kinase
-
 Mus musculus
mitogen-activated protein kinase kinase kinase kinase
-
 Homo sapiens