Literature summary for 2.7.11.25 extracted from

Deng, M.; Chen, W.L.; Takatori, A.; Peng, Z.; Zhang, L.; Mongan, M.; Parthasarathy, R.; Sartor, M.; Miller, M.; Yang, J.; Su, B.; Kao, W.W.; Xia, Y.
A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing (2006), Mol. Biol. Cell, 17, 3446-3455.

Search for more literature for 2.7.11.25

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	full-thickness skin injury markedly stimulates MEKK1 expression and activity	Mus musculus

Application

Application	Comment	Organism
medicine	role in epithelial wound healing, transmits wound signals, leading to the transcriptional activation of genes involved in ECM homeostasis, epithelial cell migration, and wound reepithelialization	Mus musculus

Cloned(Commentary)

Cloned (Comment)	Organism
expression of a MEKK1 promoter-driven beta-Gal fusion protein in Mekk1deltaKD/deltaKD mice	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	Mekk1deltaKD/deltaKD mice, MEKK1 ablation significantly delays skin wound closure and impairs activation of Jun NH2-terminal kinases, induction of plasminogen activator inhibitor 1, and restoration of cell-cell junctions of the wounded epidermis. Reconstituting MEKK1 expression with MEKK1 wild-type expression significantly accelerates wound closure	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	MEKK1 down-regulation by interfering RNA significantly delays skin wound closure and impairs activation of Jun NH2-terminal kinases, induction of plasminogen activator inhibitor 1, and restoration of cell-cell junctions of the wounded epidermis	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
corneal epithelium	-	Mus musculus	-
epidermis	-	Mus musculus	-
eye	-	Mus musculus	-
hair follicle	-	Mus musculus	-
skin	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + JNK	-	Mus musculus	ADP + phosphorylated JNK	-	?

Synonyms

Synonyms	Comment	Organism
MEKK1	-	Mus musculus
mitogen-activated protein kinase kinase kinase 1	-	Mus musculus

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Release 2023.1 (January 2023)