Any feedback?
Literature summary for 2.7.11.25 extracted from
- The MEK kinases MEKK4/Ssk2p facilitate complexity in the stress signaling responses of diverse systems (2007), J. Cell. Biochem., 101, 34-43.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Gadd45alpha | causes an increase in the activation of both the p38 and JNK pathways, but not the ERK pathway, upregulates MEKK4s kinase activity to a lesser degree as compared to Gadd45beta or Gadd45gamma | Homo sapiens | |
| Gadd45beta | causes an increase in the activation of both the p38 and JNK pathways, but not the ERK pathway | Homo sapiens | |
| Gadd45gamma | causes an increase in the activation of both the p38 and JNK pathways, but not the ERK pathway | Homo sapiens | |
| additional information | Ssk1p binds and activates the MEKK kinases Ssk2p and Ssk22p, de-phosphorylated Ssk1p binds to the N-terminal auto-inhibitory domain of Ssk2p and Ssk22p, activating their auto-phosphorylation on a conserved threonine residue | Saccharomyces cerevisiae |
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | Ssk2p is one of the three MEKK kinases in the HOG pathway, the other two being Ste11p and Ssk22p, Ssk2p is homologous to MEKK4, monitors the integrity of the actin cytoskeleton and regulates its recovery from osmotic stress | Saccharomyces cerevisiae |
| additional information | two isoforms of MEKK4, monitors the integrity of the actin cytoskeleton and regulates its recovery from osmotic stress, MEKK4 and TRAF4 are involved in the process of neurulation | Homo sapiens |
| additional information | two isoforms of MEKK4, play a role in downregulating apoptosis during neurulation via the p38 MAPK pathway | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in COS-7 cells and in yeast | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K1361R | shows remarkable increase in the number of neural tube defects | Mus musculus |
| additional information | deletion of the CRIB domain of MEKK4 diminishes but does not abolish Cdc42 binding | Homo sapiens |
| additional information | MEKK4-/- mice, protein is not essential for embryonic survival, but more than 80% of mice exhibit neural tube defects and die shortly after birth. Reduced level of IFN-gamma production in response to cytokine treatment. MEKK4-3R mutant, completely abolishes CIN85 interaction and is defective in activating the p38 pathway. Intermediate MKK6 causes reduction in p38 activation in response to both oxidative stress and epidermal growth factor stimulation, less prone to ubiquitination | Mus musculus |
| additional information | ssk2delta/ssk22delta/ste11delta strain, complementation of the osmo-sensitive phenotype, deletion of the LD domain of Ssk2p results in a serious localization defect when yeast cells are exposed to osmotic stress as well as an inability to facilitate the actin specific functions of Ssk2p | Saccharomyces cerevisiae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | inhibitory function within the N-terminal domain | Homo sapiens | |
| additional information | inhibitory function within the N-terminal domain | Saccharomyces cerevisiae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | - |
Mus musculus | - |
| keratinocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + cdc42 | - |
Homo sapiens | ADP + phosphorylated cdc42 | - |
? |  |
| ATP + MKK3 | - |
Drosophila melanogaster | ADP + phosphorylated MKK3 | - |
? | |
| ATP + MKK3 | - |
Mus musculus | ADP + phosphorylated MKK3 | - |
? | |
| ATP + MKK3 | - |
Homo sapiens | ADP + phosphorylated MKK3 | - |
? | |
| ATP + MKK4 | - |
Drosophila melanogaster | ADP + phosphorylated MKK4 | - |
? | |
| ATP + MKK4 | - |
Mus musculus | ADP + phosphorylated MKK4 | - |
? | |
| ATP + MKK4 | - |
Homo sapiens | ADP + phosphorylated MKK4 | - |
? | |
| ATP + MKK6 | - |
Drosophila melanogaster | ADP + phosphorylated MKK6 | - |
? | |
| ATP + MKK6 | - |
Mus musculus | ADP + phosphorylated MKK6 | - |
? | |
| ATP + MKK6 | - |
Homo sapiens | ADP + phosphorylated MKK6 | - |
? | |
| ATP + Pbs2p | - |
Saccharomyces cerevisiae | ADP + phosphorylated Pbs2p | - |
? | |
| ATP + Rac | - |
Homo sapiens | ADP + phosphorylated Rac | - |
? | |
| additional information | MEKK4 is a signaling protein of the p38 MAPK pathway | Drosophila melanogaster | ? | - |
? | |
| additional information | MEKK4 is a signaling protein of the p38 MAPK pathway | Mus musculus | ? | - |
? | |
| additional information | MEKK4 is a signaling protein of the p38 MAPK pathway | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| D-MEKK1 | - |
Drosophila melanogaster |
| D-MEKK1 | - |
Mus musculus |
| MAP kinase kinase kinase | - |
Drosophila melanogaster |
| MAP kinase kinase kinase | - |
Mus musculus |
| MAP kinase kinase kinase | - |
Homo sapiens |
| MAP kinase kinase kinase | - |
Saccharomyces cerevisiae |
| MAPKKK | - |
Drosophila melanogaster |
| MAPKKK | - |
Mus musculus |
| MAPKKK | - |
Homo sapiens |
| MAPKKK | - |
Saccharomyces cerevisiae |
| MEKK4 | - |
Homo sapiens |
| Ssk22p | - |
Saccharomyces cerevisiae |
| Ssk2p | - |
Saccharomyces cerevisiae |
| Ste11p | - |
Saccharomyces cerevisiae |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
