Application | Comment | Organism |
---|---|---|
medicine | MEKK4 is a critical signaling molecule during cardiovascular development, plays an important role in cardiac cushion morphogenesis, kinase activity of MEKK4 is essential, but not sufficient, to support developmental epithelial to mesenchymal transformation | Mus musculus |
Cloned (Comment) | Organism |
---|---|
into pBluescript, SF-9 insect cells infected with baculovirus expressing either MEKK4 or the kinase inactive form of MEKK4 | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | kinase inactive form of MEKK4, attenuates mesenchyme production | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | MEKK4 mRNA is detected from stages embryonic day 8.5 through 14.5 encompassing prelooped, looping, cushion morphogenesis, and completed septation stages of heart development. MEKK4 protein is detected to the developing heart at stages embryonic day 10.5 to 14.5 | Mus musculus | - |
endothelial cell | - |
Mus musculus | - |
heart | detection of MEKK4 transcripts to early myocardium, endocardium and to cardiac cushion cells that have executed epithelial to mesenchymal transformation | Mus musculus | - |
heart ventricle | - |
Mus musculus | - |
mesenchyme | - |
Mus musculus | - |
additional information | atrioventricular canal | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + MKK6 | - |
Mus musculus | ADP + phosphorylated MKK6 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAP kinase kinase kinase | - |
Mus musculus |
MEKK4 | - |
Mus musculus |