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Literature summary for 2.7.11.25 extracted from

  • Robitaille, H.; Proulx, R.; Robitaille, K.; Blouin, R.; Germain, L.
    The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation (2005), J. Biol. Chem., 280, 12732-12741.
    View publication on PubMed
Search for more literature for 2.7.11.25

Cloned(Commentary)

Cloned (Comment) Organism
expression of DLK in cultured keratinocytes using the adenovirus transfection method Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information overexpression of DLK in cultured keratinocytes results in altered features of the cell concerning suprabasal localization, cell shape, compacted cytoplasm, DNA fragmentation, and regulation of filaggrin expression, which is upregulated, terminally differentiated phenotype, the transglutaminase activity is increased leading to cornified cell envelope formation, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens DLK acts as a key regulator of keratinocyte terminal differentiation, and is involved in activation of the JNK signaling pathway, DLK activity is required for transglutaminase activation and induction of keratinocyte cornification ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium of skin Homo sapiens
-
keratinocyte DLK acts as a key regulator of keratinocyte terminal differentiation and cornification Homo sapiens
-
skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + myelin basic protein
-
 Homo sapiens ADP + phosphorylated myelin basic protein
-
 ?
additional information DLK acts as a key regulator of keratinocyte terminal differentiation, and is involved in activation of the JNK signaling pathway, DLK activity is required for transglutaminase activation and induction of keratinocyte cornification Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More DLK is a dual leucine zipper-bearing protein Homo sapiens

Synonyms

Synonyms Comment Organism
DLK
-
 Homo sapiens
dual leucine zipper-bearing kinase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens