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Literature summary for 2.7.11.25 extracted from

  • Takahashi, M.; Gotoh, Y.; Isagawa, T.; Nishimura, T.; Goyama, E.; Kim, H.S.; Mukai, H.; Ono, Y.
    Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN (2003), J. Biochem., 133, 181-187.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information MLTKalpha is activated by phosphorylation through PKNalpha Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and inactive mutant enzymes in HEK293T cells and in COS-7 cells as HA-tagged proteins Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of a kinase-defective MTLKalpha mutant, expression of a kinase-defective PKNalpha mutant results in inhibition of MLTKalpha activity and p38 kinase induction Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + MKK3 Homo sapiens activation of the p38 MAP kinase signaling pathway ADP + phosphorylated MKK3
-
?
ATP + MKK6 Homo sapiens activation of the p38 MAP kinase signaling pathway ADP + phosphorylated MKK6
-
?
additional information Homo sapiens MLTKalpha activates the p38gamma MAPK-dependent signaling pathway, which is regulated by the serine/threonine kinase PKNalpha ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein MLTKalpha is phosphorylated by PKNalpha, probably at the C-terminal alpha-motif Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + MKK3 a MAPKK Homo sapiens ADP + phosphorylated MKK3
-
?
ATP + MKK3 activation of the p38 MAP kinase signaling pathway Homo sapiens ADP + phosphorylated MKK3
-
?
ATP + MKK6 a MAPKK Homo sapiens ADP + phosphorylated MKK6
-
?
ATP + MKK6 activation of the p38 MAP kinase signaling pathway Homo sapiens ADP + phosphorylated MKK6
-
?
additional information MLTKalpha activates the p38gamma MAPK-dependent signaling pathway, which is regulated by the serine/threonine kinase PKNalpha Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
More the MLTKalpha C-terminus possesses an alpha-motif in vicinity to the leucine zipper, the alpha-motif is supposed to be a regulatory and phosphorylation site Homo sapiens

Synonyms

Synonyms Comment Organism
MAPK kinase kinase
-
Homo sapiens
MAPKKK
-
Homo sapiens
MLK-like mitogen-activated protein triple kinase
-
Homo sapiens
MLTKalpha
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens