Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | MLTKalpha is activated by phosphorylation through PKNalpha | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of wild-type and inactive mutant enzymes in HEK293T cells and in COS-7 cells as HA-tagged proteins | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a kinase-defective MTLKalpha mutant, expression of a kinase-defective PKNalpha mutant results in inhibition of MLTKalpha activity and p38 kinase induction | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + MKK3 | Homo sapiens | activation of the p38 MAP kinase signaling pathway | ADP + phosphorylated MKK3 | - |
? | |
ATP + MKK6 | Homo sapiens | activation of the p38 MAP kinase signaling pathway | ADP + phosphorylated MKK6 | - |
? | |
additional information | Homo sapiens | MLTKalpha activates the p38gamma MAPK-dependent signaling pathway, which is regulated by the serine/threonine kinase PKNalpha | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | MLTKalpha is phosphorylated by PKNalpha, probably at the C-terminal alpha-motif | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + MKK3 | a MAPKK | Homo sapiens | ADP + phosphorylated MKK3 | - |
? | |
ATP + MKK3 | activation of the p38 MAP kinase signaling pathway | Homo sapiens | ADP + phosphorylated MKK3 | - |
? | |
ATP + MKK6 | a MAPKK | Homo sapiens | ADP + phosphorylated MKK6 | - |
? | |
ATP + MKK6 | activation of the p38 MAP kinase signaling pathway | Homo sapiens | ADP + phosphorylated MKK6 | - |
? | |
additional information | MLTKalpha activates the p38gamma MAPK-dependent signaling pathway, which is regulated by the serine/threonine kinase PKNalpha | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the MLTKalpha C-terminus possesses an alpha-motif in vicinity to the leucine zipper, the alpha-motif is supposed to be a regulatory and phosphorylation site | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
MAPK kinase kinase | - |
Homo sapiens |
MAPKKK | - |
Homo sapiens |
MLK-like mitogen-activated protein triple kinase | - |
Homo sapiens |
MLTKalpha | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |