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Literature summary for 2.7.11.25 extracted from

  • Takeda, K.; Matsuzawa, A.; Nishitoh, H.; Ichijo, H.
    Roles of MAPKKK ASK1 in stress-induced cell death (2003), Cell Struct. Funct., 28, 23-29.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information polymerization and phosphorylation activates the enzyme after dissociation of thioredoxin due to TNF-alpha treatment Mus musculus
additional information polymerization and phosphorylation activates the enzyme after dissociation of thioredoxin due to TNF-alpha treatment Homo sapiens
reactive oxygene species the enzyme is oxidative stress-induced Mus musculus
reactive oxygene species the enzyme is oxidative stress-induced Homo sapiens
TNF-alpha treatment with TNF-alpha dissociates the inhibitor thioredoxin from the enzyme's N-terminus Mus musculus
TNF-alpha treatment with TNF-alpha dissociates the inhibitor thioredoxin from the enzyme's N-terminus Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
thioredoxin the reduced form binds to the N-terminus Homo sapiens
thioredoxin the reduced form binds to the N-terminus Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + MKK3 Mus musculus activation of the p38 MAP kinase signaling pathway leading to apoptosis ADP + phosphorylated MKK3
-
?
ATP + MKK3 Homo sapiens activation of the p38 MAP kinase signaling pathway leading to apoptosis ADP + phosphorylated MKK3
-
?
ATP + MKK4 Mus musculus activation of the Jun N-terminal kinase, JNK, pathway leading to apoptosis ADP + phosphorylated MKK4
-
?
ATP + MKK4 Homo sapiens activation of the Jun N-terminal kinase, JNK, pathway leading to apoptosis ADP + phosphorylated MKK4
-
?
ATP + MKK6 Mus musculus activation of the p38 MAP kinase signaling pathway leading to apoptosis ADP + phosphorylated MKK6
-
?
ATP + MKK6 Homo sapiens activation of the p38 MAP kinase signaling pathway leading to apoptosis ADP + phosphorylated MKK6
-
?
ATP + MKK7 Mus musculus activation of the Jun N-terminal kinase, JNK, signaling pathway leading to apoptosis ADP + phosphorylated MKK7
-
?
ATP + MKK7 Homo sapiens activation of the Jun N-terminal kinase, JNK, signaling pathway leading to apoptosis ADP + phosphorylated MKK7
-
?
additional information Mus musculus activation mechanism of ASK1, overview, ASK1 is involved in oxidative stress-induced cell death and adaptation processes to various stresses, the enzyme is required for induction of apoptosis by e.g. Fas or TNF-alpha, or by the endoplasmic reticulum, mechanism ?
-
?
additional information Homo sapiens activation mechanism of ASK1, overview, ASK1 is involved in oxidative stress-induced cell death and adaptation processes to various stresses, the enzyme is required for induction of apoptosis by e.g. Fas or TNF-alpha, or by the endoplasmic reticulum, mechanism, ASK1 plays an important role in neuropathological alterations in polyQ diseases ?
-
?
additional information Caenorhabditis elegans NSY-1 functions in the control of asymmetric expression of odor receptor gene str-2, odor discrimination, and odor chemotaxis, thus possibly in functional differentiation of the nervous system, the enzyme functions downstream of UNC-43 CaMKII ?
-
?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation activates the enzyme Mus musculus
phosphoprotein phosphorylation activates the enzyme Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate mechanism of ASK1 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
neuron
-
Mus musculus
-
neuron
-
Homo sapiens
-
olfactory neuron
-
Caenorhabditis elegans
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + MKK3 a MAPKK Mus musculus ADP + phosphorylated MKK3
-
?
ATP + MKK3 a MAPKK Homo sapiens ADP + phosphorylated MKK3
-
?
ATP + MKK3 activation of the p38 MAP kinase signaling pathway leading to apoptosis Mus musculus ADP + phosphorylated MKK3
-
?
ATP + MKK3 activation of the p38 MAP kinase signaling pathway leading to apoptosis Homo sapiens ADP + phosphorylated MKK3
-
?
ATP + MKK4 activation of the Jun N-terminal kinase, JNK, pathway leading to apoptosis Mus musculus ADP + phosphorylated MKK4
-
?
ATP + MKK4 activation of the Jun N-terminal kinase, JNK, pathway leading to apoptosis Homo sapiens ADP + phosphorylated MKK4
-
?
ATP + MKK4 i.e. SEK1, a MAPKK Mus musculus ADP + phosphorylated MKK4
-
?
ATP + MKK4 i.e. SEK1, a MAPKK Homo sapiens ADP + phosphorylated MKK4
-
?
ATP + MKK6 a MAPKK Mus musculus ADP + phosphorylated MKK6
-
?
ATP + MKK6 a MAPKK Homo sapiens ADP + phosphorylated MKK6
-
?
ATP + MKK6 activation of the p38 MAP kinase signaling pathway leading to apoptosis Mus musculus ADP + phosphorylated MKK6
-
?
ATP + MKK6 activation of the p38 MAP kinase signaling pathway leading to apoptosis Homo sapiens ADP + phosphorylated MKK6
-
?
ATP + MKK7 a MAPKK Mus musculus ADP + phosphorylated MKK7
-
?
ATP + MKK7 a MAPKK Homo sapiens ADP + phosphorylated MKK7
-
?
ATP + MKK7 activation of the Jun N-terminal kinase, JNK, signaling pathway leading to apoptosis Mus musculus ADP + phosphorylated MKK7
-
?
ATP + MKK7 activation of the Jun N-terminal kinase, JNK, signaling pathway leading to apoptosis Homo sapiens ADP + phosphorylated MKK7
-
?
additional information activation mechanism of ASK1, overview, ASK1 is involved in oxidative stress-induced cell death and adaptation processes to various stresses, the enzyme is required for induction of apoptosis by e.g. Fas or TNF-alpha, or by the endoplasmic reticulum, mechanism Mus musculus ?
-
?
additional information activation mechanism of ASK1, overview, ASK1 is involved in oxidative stress-induced cell death and adaptation processes to various stresses, the enzyme is required for induction of apoptosis by e.g. Fas or TNF-alpha, or by the endoplasmic reticulum, mechanism, ASK1 plays an important role in neuropathological alterations in polyQ diseases Homo sapiens ?
-
?
additional information NSY-1 functions in the control of asymmetric expression of odor receptor gene str-2, odor discrimination, and odor chemotaxis, thus possibly in functional differentiation of the nervous system, the enzyme functions downstream of UNC-43 CaMKII Caenorhabditis elegans ?
-
?

Synonyms

Synonyms Comment Organism
apoptosis signal-regulating kinase 1
-
Mus musculus
apoptosis signal-regulating kinase 1
-
Homo sapiens
ASK1
-
Mus musculus
ASK1
-
Homo sapiens
MAPKKK
-
Mus musculus
MAPKKK
-
Homo sapiens
NSY-1
-
Caenorhabditis elegans

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus
ATP
-
Homo sapiens