Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | pathogen-associated molecular patterns (PAMPs) are recognized by plant pattern recognition receptors to activate PAMP-triggered immunity. PAMP perception enhances phosphorylation of BES1. Flagellin perception, e.g. of Flg22, enhances BES1 phosphorylation. Enzyme MKK5 phosphorylates and activates MPK6 | Arabidopsis thaliana |
Cloned (Comment) | Organism |
---|---|
recombinant expression of GST-tagged MPK6, coexpression of His-tagged BES1 and GST-tagged MPK6 in Nicotiana benthamiana, interaction analysis | Arabidopsis thaliana |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
protoplast | - |
Arabidopsis thaliana | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Arabidopsis thaliana |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + BES1 | Arabidopsis thaliana | i.e. brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1, an Arabidospis thaliana transcription factor. S286 and S137 residues are required for flg22-induced BES1 full phosphorylation in vivo, in which S286 plays a greater role than S137 | ADP + phosphorylated BES1 | - |
? | |
ATP + BES1 | Arabidopsis thaliana Col-0 | i.e. brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1, an Arabidospis thaliana transcription factor. S286 and S137 residues are required for flg22-induced BES1 full phosphorylation in vivo, in which S286 plays a greater role than S137 | ADP + phosphorylated BES1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | Q39026 | - |
- |
Arabidopsis thaliana Col-0 | Q39026 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | enzyme MKK5 phosphorylates and activates MPK6 | Arabidopsis thaliana |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + BES1 | i.e. brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1, an Arabidospis thaliana transcription factor. S286 and S137 residues are required for flg22-induced BES1 full phosphorylation in vivo, in which S286 plays a greater role than S137 | Arabidopsis thaliana | ADP + phosphorylated BES1 | - |
? | |
ATP + BES1 | i.e. brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1, an Arabidospis thaliana transcription factor | Arabidopsis thaliana | ADP + phosphorylated BES1 | - |
? | |
ATP + BES1 | i.e. brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1, an Arabidospis thaliana transcription factor. S286 and S137 residues are required for flg22-induced BES1 full phosphorylation in vivo, in which S286 plays a greater role than S137 | Arabidopsis thaliana Col-0 | ADP + phosphorylated BES1 | - |
? | |
ATP + BES1 | i.e. brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1, an Arabidospis thaliana transcription factor | Arabidopsis thaliana Col-0 | ADP + phosphorylated BES1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAPK | - |
Arabidopsis thaliana |
mitogen-activated protein kinase6 | - |
Arabidopsis thaliana |
MPK6 | - |
Arabidopsis thaliana |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Arabidopsis thaliana |
General Information | Comment | Organism |
---|---|---|
metabolism | pathogen-associated molecular patterns (PAMPs) are recognized by plant pattern recognition receptors to activate PAMP-triggered immunity. PAMP perception enhances phosphorylation of BES1. BES1 is a unique direct substrate of MPK6 in PAMP-triggered immunity signaling. MAPK-mediated BES1 phosphorylation is another BES1 modulation mechanism in plant cell signaling, in addition to GSK3-like kinase-mediated BES1 phosphorylation and F box protein-mediated BES1 degradation. BES1 phosphorylation induced by flg22 occurs downstream of MAPK activation. MKK5K99M acts as a dominant negative mutant that partially blocks MAPK activation and downstream PTI signaling | Arabidopsis thaliana |
physiological function | brassinosteroid insensitive1-ethyl methanesulfonate-suppressor1, BES1, is phosphorylted by Arabidospis thaliana MPK6. MAPK-mediated phosphorylation alters BES1 subcellular accumulation in PAMP-triggered immunity | Arabidopsis thaliana |