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Literature summary for 2.7.11.24 extracted from

  • Choi, Y.H.; Yang, D.J.; Kulkarni, A.; Moh, S.H.; Kim, K.W.
    Mycosporine-like amino acids promote wound healing through focal adhesion kinase (FAK) and mitogen-activated protein kinases (MAP kinases) signaling pathway in keratinocytes (2015), Mar. Drugs, 13, 7055-7066.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information activation of ERK by FAK in turn phosphorylates FAK at S910, which promotes the disassembly of focal adhesion (hemidesmosome disruption) during cell migration Homo sapiens
mycosporine-glycine mycosporine-like amino acids shinorine, mycosporine-glycine, and porphyra are purified from Chlamydomonas hedlyei and Porphyra yezoensis activate kinase ERK and JNK, especially JNK Homo sapiens
porphyra mycosporine-like amino acids shinorine, mycosporine-glycine, and porphyra are purified from Chlamydomonas hedlyei and Porphyra yezoensis activate kinase ERK and JNK, especially JNK Homo sapiens
shinorine mycosporine-like amino acids shinorine, mycosporine-glycine, and porphyra are purified from Chlamydomonas hedlyei and Porphyra yezoensis activate kinase ERK and JNK, especially JNK Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
PD98059 an ERK inhibitor; an ERK inhibitor Homo sapiens
SP600125 a JNK inhibitor Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27361
-
-
Homo sapiens P28482
-
-
Homo sapiens P45983
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation through focal adhesion kinase activates ERK, which susequently leads to phosphorylation of focal adhesion kinase through phosphorylated ERK, which promotes the disassembly of focal adhesion (hemidesmosome disruption) during cell migration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HaCaT cell
-
Homo sapiens
-
keratinocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + focal adhesion kinase phosphorylation of FAK at S910, which promotes the disassembly of focal adhesion (hemidesmosome disruption) during cell migration Homo sapiens ADP + phosphorylated focal adhesion kinase
-
?

Synonyms

Synonyms Comment Organism
c-Jun N-terminal kinase
-
Homo sapiens
ERK1
-
Homo sapiens
ERK2
-
Homo sapiens
extracellular signal-regulated kinase
-
Homo sapiens
JNK1
-
Homo sapiens
MAPK
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

General Information

General Information Comment Organism
malfunction ERK inhibition using PD98059 causes reduction of wound healing by up to 15% Homo sapiens
malfunction inhibition of JNK completely blocks mycosporine-like amino acids-mediated wound closure Homo sapiens
metabolism mycosporine-like amino acids promote wound healing through focal adhesion kinase (FAK, EC 2.7.10.2) and mitogen-activated protein kinases (MAP kinases) signaling pathway in keratinocytes Homo sapiens
metabolism mycosporine-like amino acids promote wound healing through focal adhesion kinase (FAK, EC 2.7.10.2, HaCaT cells) and mitogen-activated protein kinases (MAP kinases) signaling pathway in keratinocytes Homo sapiens
physiological function JNK is a factor involved in inflammation, proliferation, and apoptosis. In addition JNK is essential for cell migration and keratinocyte movement through phosphorylation of paxillin. Activation of JNK1 is involved in wound repair. The activation of JNK is involved in the mycosporine-like amino acid-induced cell migration Homo sapiens