Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activation of ERK by FAK in turn phosphorylates FAK at S910, which promotes the disassembly of focal adhesion (hemidesmosome disruption) during cell migration | Homo sapiens | |
mycosporine-glycine | mycosporine-like amino acids shinorine, mycosporine-glycine, and porphyra are purified from Chlamydomonas hedlyei and Porphyra yezoensis activate kinase ERK and JNK, especially JNK | Homo sapiens | |
porphyra | mycosporine-like amino acids shinorine, mycosporine-glycine, and porphyra are purified from Chlamydomonas hedlyei and Porphyra yezoensis activate kinase ERK and JNK, especially JNK | Homo sapiens | |
shinorine | mycosporine-like amino acids shinorine, mycosporine-glycine, and porphyra are purified from Chlamydomonas hedlyei and Porphyra yezoensis activate kinase ERK and JNK, especially JNK | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PD98059 | an ERK inhibitor; an ERK inhibitor | Homo sapiens | |
SP600125 | a JNK inhibitor | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27361 | - |
- |
Homo sapiens | P28482 | - |
- |
Homo sapiens | P45983 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation through focal adhesion kinase activates ERK, which susequently leads to phosphorylation of focal adhesion kinase through phosphorylated ERK, which promotes the disassembly of focal adhesion (hemidesmosome disruption) during cell migration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HaCaT cell | - |
Homo sapiens | - |
keratinocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + focal adhesion kinase | phosphorylation of FAK at S910, which promotes the disassembly of focal adhesion (hemidesmosome disruption) during cell migration | Homo sapiens | ADP + phosphorylated focal adhesion kinase | - |
? |
Synonyms | Comment | Organism |
---|---|---|
c-Jun N-terminal kinase | - |
Homo sapiens |
ERK1 | - |
Homo sapiens |
ERK2 | - |
Homo sapiens |
extracellular signal-regulated kinase | - |
Homo sapiens |
JNK1 | - |
Homo sapiens |
MAPK | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | ERK inhibition using PD98059 causes reduction of wound healing by up to 15% | Homo sapiens |
malfunction | inhibition of JNK completely blocks mycosporine-like amino acids-mediated wound closure | Homo sapiens |
metabolism | mycosporine-like amino acids promote wound healing through focal adhesion kinase (FAK, EC 2.7.10.2) and mitogen-activated protein kinases (MAP kinases) signaling pathway in keratinocytes | Homo sapiens |
metabolism | mycosporine-like amino acids promote wound healing through focal adhesion kinase (FAK, EC 2.7.10.2, HaCaT cells) and mitogen-activated protein kinases (MAP kinases) signaling pathway in keratinocytes | Homo sapiens |
physiological function | JNK is a factor involved in inflammation, proliferation, and apoptosis. In addition JNK is essential for cell migration and keratinocyte movement through phosphorylation of paxillin. Activation of JNK1 is involved in wound repair. The activation of JNK is involved in the mycosporine-like amino acid-induced cell migration | Homo sapiens |