Literature summary for 2.7.11.24 extracted from

Onali, P.; Dedoni, S.; Olianas, M.C.
Direct agonist activity of tricyclic antidepressants at distinct opioid receptor subtypes (2010), J. Pharmacol. Exp. Ther., 332, 255-265.

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Activating Compound

Activating Compound	Comment	Organism	Structure
amitriptyline	up-regulates ERK1/2 phosphorylation and activity 8fold at 0.01 mM, the addition of nor-binaltorphimine (100 nM) reduces the amitriptyline stimulatory effect by 70%	Homo sapiens
amitriptyline	up-regulates ERK1/2 phosphorylation and activity 8fold at 0.01 mM, the addition of nor-binaltorphimine (100 nM) reduces the amitriptyline stimulatory effect by 70%	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in CHO/KOR cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	-	Homo sapiens
phosphoprotein	-	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
C6 glioma cell	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
ERK1/2	-	Homo sapiens
ERK1/2	-	Rattus norvegicus
extracellular signal-regulated kinase 1/2	-	Homo sapiens
extracellular signal-regulated kinase 1/2	-	Rattus norvegicus

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Release 2023.1 (January 2023)