Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.24 extracted from

  • Chang, Y.; Wang, S.J.
    Hypericin, the active component of St. Johns wort, inhibits glutamate release in the rat cerebrocortical synaptosomes via a mitogen-activated protein kinase-dependent pathway (2010), Eur. J. Pharmacol., 634, 53-61.
    View publication on PubMed
Search for more literature for 2.7.11.24

Inhibitors

Inhibitors Comment Organism Structure
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one PD98059 Rattus norvegicus
hypericin hypericin-mediated inhibition of glutamate release appears to involve the suppression of mitogen-activated protein kinase pathway Rattus norvegicus
U0126
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
synaptosome
-
 Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Rattus norvegicus
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley rat
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebral cortex
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Rattus norvegicus ADP + a phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
MAP kinase
-
 Rattus norvegicus
mitogen-activated kinase
-
 Rattus norvegicus
mitogen-activated protein kinase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function the mitogen-activated protein kinase signaling pathway is one of the major second messenger systems regulating glutamate release at the presynaptic level Rattus norvegicus