Activating Compound | Comment | Organism | Structure |
---|---|---|---|
interleukin-I | - |
Homo sapiens | |
lipopolysaccharide | - |
Homo sapiens | |
additional information | activated by growth factors, cellular stresses, and cytokines | Homo sapiens | |
tumor necrosis factor-alpha | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-tert-butyl-N-cyclopropyl-2-methoxy-3-[2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetylamino]-benzamide | KR-003048 | Homo sapiens | |
BIRB796 | - |
Homo sapiens | |
SB203580 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
THP-1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
ATP + myelin basic protein | substrate in in vitro kinase assay | Homo sapiens | ADP + phosphorylated myelin basic protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAP kinase | - |
Homo sapiens |
mitogen-activated kinase | - |
Homo sapiens |
p38 mitogen-activated protein kinase | - |
Homo sapiens |
p38alpha | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
kinase assay | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
kinase assay | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000022 | - |
- |
Homo sapiens | 5-tert-butyl-N-cyclopropyl-2-methoxy-3-[2-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-2-oxo-acetylamino]-benzamide | |
0.000033 | - |
- |
Homo sapiens | SB203580 | |
0.000035 | - |
- |
Homo sapiens | BIRB796 |
General Information | Comment | Organism |
---|---|---|
physiological function | monocyte, macrophage production of tumor necrosis factor-alpha is largely driven by p38 mitogen-activated protein kinase | Homo sapiens |