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Literature summary for 2.7.11.24 extracted from

  • Fahrenholz, M.; Real, R.; Kueken, A.; Saxena, A.; Orzechowski, H.D.
    Single low-dose administration of pharmacological inhibitor of mitogen-activated ERK kinase to the adventitia of the injured rat carotid artery suppresses neointima formation and inhibits nuclear ERK signaling (2009), Eur. J. Pharmacol., 617, 90-96.
    View publication on PubMed
Search for more literature for 2.7.11.24

Activating Compound

Activating Compound Comment Organism Structure
additional information arterial injury activates the mitogen-activated ERK kinase/extracellular signal-regulated kinase signaling pathway Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2-(2'-amino-3'-methoxyphenyl)oxanaphthalen-4-one PD98059 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Rattus norvegicus
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley rat
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
carotid artery
-
 Rattus norvegicus
-
vascular smooth muscle cell line VSMC culture Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Rattus norvegicus ADP + a phosphoprotein
-
 ?
ATP + Ets-1
-
 Rattus norvegicus ADP + phosphorylated Ets-1
-
 ?

Synonyms

Synonyms Comment Organism
ERK1/2
-
 Rattus norvegicus
MAP kinase
-
 Rattus norvegicus
MEK
-
 Rattus norvegicus
mitogen-activated ERK kinase
-
 Rattus norvegicus
mitogen-activated kinase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus