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Literature summary for 2.7.11.24 extracted from
- Inhibitors of p38 mitogen-activated protein kinase enhance proliferation of mouse neural stem cells (2008), J. Neurosci. Res., 86, 2179-2189.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| SB202190 | a p38 MAPK specific inhibitor | Mus musculus |  |
| SB203580 | a p38 MAPK specific inhibitor | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | p38 MAPK is induced in response to environmental stress, it is implicated in diverse cellular processes, including cell proliferation, differentiation, and survival of differentiated cells in the central nervous system, expression profile and roles of p38 MAPK in the developing brain, overview. Inhibitors of p38 mitogen-activated protein kinase enhance proliferation of mouse neural stem cells, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | p38 MAPK is expressed predominantly in nestin-positive cells in the cerebral cortex in embryonic day 10 brain, the expression of the protein decreases gradually during development | Mus musculus | - |
| cell culture | primary cultures prepared from embryonic mouse brains, i.e. cerebral hemisphere and thalamus | Mus musculus | - |
| embryo | p38 MAPK is expressed predominantly in nestin-positive cells in the cerebral cortex in embryonic day 10 brain | Mus musculus | - |
| neural stem cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | p38 MAPK is induced in response to environmental stress, it is implicated in diverse cellular processes, including cell proliferation, differentiation, and survival of differentiated cells in the central nervous system, expression profile and roles of p38 MAPK in the developing brain, overview. Inhibitors of p38 mitogen-activated protein kinase enhance proliferation of mouse neural stem cells, overview | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| p38 MAPK | - |
Mus musculus |
| p38 mitogen-activated protein kinase | - |
Mus musculus |
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