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Literature summary for 2.7.11.24 extracted from

  • Binet, F.; Girard, D.
    Novel human neutrophil agonistic properties of arsenic trioxide: involvement of p38 mitogen-activated protein kinase and/or c-jun NH2-terminal MAPK but not extracellular signal-regulated kinases-1/2 (2008), J. Leukoc. Biol., 84, 1613-1622.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information arsenic trioxide induces apoptosis and mitogen-activated protein kinases in promyelocytes and cancer cells. It enhances adhesion, migration, phagocytosis, release, and activity of gelatinase and degranulation of secretory, specific, and gelatinase, but not azurophilic granules, and is dependent upon activation of p38 and/or JNK. Activation of p38 and JNK is not associated with the ability of arsenic trioxide to induce human neutrophil apoptosis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
PD98059 inhibits ERK1/2 or JNK Homo sapiens
SB203580 inhibits p38 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens arsenic trioxide induces apoptosis and mitogen-activated protein kinases in promyelocytes and cancer cells. It enhances adhesion, migration, phagocytosis, release, and activity of gelatinase and degranulation of secretory, specific, and gelatinase, but not azurophilic granules, and is dependent upon activation of p38 and/or JNK. Activation of p38 and JNK is not associated with the ability of arsenic trioxide to induce human neutrophil apoptosis, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell human lung epithelial cell line Homo sapiens
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neutrophil
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information arsenic trioxide induces apoptosis and mitogen-activated protein kinases in promyelocytes and cancer cells. It enhances adhesion, migration, phagocytosis, release, and activity of gelatinase and degranulation of secretory, specific, and gelatinase, but not azurophilic granules, and is dependent upon activation of p38 and/or JNK. Activation of p38 and JNK is not associated with the ability of arsenic trioxide to induce human neutrophil apoptosis, overview Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
c-jun NH2-terminal MAPK
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 Homo sapiens
ERK1/2
-
 Homo sapiens
extracellular signal-regulated kinases-1/2
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 Homo sapiens
JNK
-
 Homo sapiens
p38
-
 Homo sapiens
p38 mitogen-activated protein kinase
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 Homo sapiens