Literature summary for 2.7.11.24 extracted from

Abidi, P.; Zhang, H.; Zaidi, S.M.; Shen, W.J.; Leers-Sucheta, S.; Cortez, Y.; Han, J.; Azhar, S.
Oxidative stress-induced inhibition of adrenal steroidogenesis requires participation of p38 mitogen-activated protein kinase signaling pathway (2008), J. Endocrinol., 198, 193-207.

Search for more literature for 2.7.11.24

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	H2O2 and 4-hydroxy-2-nonenal increase phosphorylation and activation of p38 MAPK, but not of ERK1/2	Mus musculus
additional information	no activation JNK1 by H2O2 and 4-hydroxy-2-nonenal	Mus musculus
additional information	no activation JNK2 by H2O2 and 4-hydroxy-2-nonenal	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
SB202190	inhibitor of p38 MAPKalpha, little or no inhibition of p38 MAPK beta, gamma, and delta	Mus musculus
SB203580	inhibitor of p38 MAPKalpha, little or no inhibition of p38 MAPK beta, gamma, and delta	Mus musculus
SP600125	inhibitor of JNK; inhibitor of JNK	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	activated p39 MAPK inhibits steroid synthesis in adrenocortical Y1-BS1 cells, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Mus musculus	Q91Y86	JNK1	-
Mus musculus	Q9WTU6	JNK2	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	JNK is activated by phosphorylation at Thr183 and Tyr185 through MKKs	Mus musculus
phosphoprotein	p38 and ERK1/2 are activated by phosphorylation at Thr180 and Tyr182, or Thr202 and Tyr204, respectively, through MKKs	Mus musculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
Y1-BS1 cell	adrenocortical cell line	Mus musculus	-
Y1-BS1 cell	adrenocortical cell line, predominant expression of isozyme p38 MAPKalpha	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + ATF2	phosphorylation by p38 MAPK at threonine residues	Mus musculus	ADP + phosphorylated ATF2	-	?
additional information	activated p39 MAPK inhibits steroid synthesis in adrenocortical Y1-BS1 cells, overview	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
c-Jun N-terminal kinase	-	Mus musculus
ERK	-	Mus musculus
extracellular regulated kinase	-	Mus musculus
JNK	-	Mus musculus
JNK1	-	Mus musculus
JNK2	-	Mus musculus
p38 MAPK	-	Mus musculus
p38 mitogen-activated protein kinase	-	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)