Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-[1-(2-chlorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
6-[1-(2-fluorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
6-[1-(3-chlorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
6-[1-(3-fluorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
6-[1-(4-chlorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
6-[1-(4-fluorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-1,3-benzothiazole | - |
Rattus norvegicus | |
6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-[(1R)-1-methylpropyl]-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-[(1S)-1-methylpropyl]-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
6-[4-(2-fluorophenyl)-1H-imidazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
6-[4-(2-fluorophenyl)-1H-imidazol-5-yl]-N-[(1R)-1-methylpropyl]-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
6-[4-(2-fluorophenyl)-1H-imidazol-5-yl]-N-[(1S)-1-methylpropyl]-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
6-[5-amino-1-ethyl-3-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-[(1R)-1-methylpropyl]-2,3-dihydro-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
6-[5-amino-3-(2-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-N-[(1R)-1-methylpropyl]-2,3-dihydro-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
6-[5-amino-3-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-(1-methylethyl)-2,3-dihydro-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
6-[5-amino-3-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-[(1R)-1-methylpropyl]-2,3-dihydro-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
6-[5-amino-3-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-[(1S)-1-methylpropyl]-2,3-dihydro-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
additional information | synthesis of benzothiazole based inhibitors of p38alpha MAP kinase | Rattus norvegicus | |
N-(1-methylethyl)-6-(1-phenyl-1H-pyrazol-5-yl)-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
N-(1-methylethyl)-6-(4-phenyl-1,3-oxazol-5-yl)-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
N-(1-methylethyl)-6-(4-phenyl-1H-imidazol-5-yl)-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
N-(1-methylethyl)-6-[1-(2-methylphenyl)-1H-pyrazol-5-yl]-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
N-(1-methylethyl)-6-[1-(3-methylphenyl)-1H-pyrazol-5-yl]-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
N-(1-methylethyl)-6-[1-(4-methylphenyl)-1H-pyrazol-5-yl]-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
N-ethyl-6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-1,3-benzothiazol-2-amine | - |
Rattus norvegicus | |
SB203580 | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P70618 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
p38alpha MAP kinase | - |
Rattus norvegicus |
p38alpha mitogen-activated protein kinase | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000016 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | 6-[4-(2-fluorophenyl)-1H-imidazol-5-yl]-N-[(1S)-1-methylpropyl]-1,3-benzothiazol-2-amine | |
0.0000027 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | 6-[4-(2-fluorophenyl)-1H-imidazol-5-yl]-N-[(1R)-1-methylpropyl]-1,3-benzothiazol-2-amine | |
0.0000032 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | 6-[5-amino-3-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-[(1R)-1-methylpropyl]-2,3-dihydro-1,3-benzothiazol-2-amine | |
0.0000033 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | N-(1-methylethyl)-6-(4-phenyl-1H-imidazol-5-yl)-1,3-benzothiazol-2-amine | |
0.0000033 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | 6-[4-(2-fluorophenyl)-1H-imidazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine | |
0.0000037 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | 6-[5-amino-3-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-(1-methylethyl)-2,3-dihydro-1,3-benzothiazol-2-amine | |
0.0000055 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | 6-[5-amino-3-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-[(1S)-1-methylpropyl]-2,3-dihydro-1,3-benzothiazol-2-amine | |
0.0000064 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | 6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine | |
0.0000065 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | 6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-[(1S)-1-methylpropyl]-1,3-benzothiazol-2-amine | |
0.00001 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | 6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-[(1R)-1-methylpropyl]-1,3-benzothiazol-2-amine | |
0.000011 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | 6-[5-amino-3-(2-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-N-[(1R)-1-methylpropyl]-2,3-dihydro-1,3-benzothiazol-2-amine | |
0.000012 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | N-ethyl-6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-1,3-benzothiazol-2-amine | |
0.000016 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | 6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-1,3-benzothiazol-2-amine | |
0.000017 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | 6-[5-amino-1-ethyl-3-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-[(1R)-1-methylpropyl]-2,3-dihydro-1,3-benzothiazol-2-amine | |
0.00002 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | 6-[1-(2-fluorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine | |
0.000021 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | N-(1-methylethyl)-6-(1-phenyl-1H-pyrazol-5-yl)-1,3-benzothiazol-2-amine | |
0.000021 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | N-(1-methylethyl)-6-(4-phenyl-1,3-oxazol-5-yl)-1,3-benzothiazol-2-amine | |
0.000033 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | N-(1-methylethyl)-6-[1-(3-methylphenyl)-1H-pyrazol-5-yl]-1,3-benzothiazol-2-amine | |
0.000033 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | 6-[1-(3-fluorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine | |
0.000047 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | 6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-1,3-benzothiazole | |
0.000048 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | 6-[1-(4-fluorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine | |
0.000072 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | 6-[1-(3-chlorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine | |
0.000146 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | N-(1-methylethyl)-6-[1-(2-methylphenyl)-1H-pyrazol-5-yl]-1,3-benzothiazol-2-amine | |
0.000175 | - |
inhibition of p38alpha MAP kinase | Rattus norvegicus | 6-[1-(2-chlorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine | |
0.001 | - |
above, inhibition of p38alpha MAP kinase | Rattus norvegicus | N-(1-methylethyl)-6-[1-(4-methylphenyl)-1H-pyrazol-5-yl]-1,3-benzothiazol-2-amine | |
0.001 | - |
above, inhibition of p38alpha MAP kinase | Rattus norvegicus | 6-[1-(4-chlorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine |