Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | MAPKs are activated by phosphorylation through MAPK kinases | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
II/SP600125 | inhibits SAPK/JNK; inhibits SAPK/JNK; inhibits SAPK/JNK | Mus musculus | |
additional information | PD98059 inhibits the activation of ERK1/2 with a IC50 value of 0.002 mM; PD98059 inhibits the activation of ERK1/2 with a IC50 value of 0.002 mM | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | trauma-hemorrhage suppresses MAPK phosphorylation and activation in lipopolysaccharide-unstimulated splenic dendritic cells, in lipopolysaccharide-unstimulated cells the activation is increased, modeling, overview | ? | - |
? | |
additional information | Mus musculus | trauma-hemorrhage suppresses MAPK phosphorylation and activation in lipopolysaccharide-unstimulated splenic dendritic cells, in lipopolysaccharide-unstimulated cells the activation is increased, modelling, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
male C3H/HeN mice | - |
Mus musculus | Q61831 | JNK3; male C3H/HeN mice | - |
Mus musculus | Q91Y86 | JNK1; male C3H/HeN mice | - |
Mus musculus | Q9WTU6 | JNK2; male C3H/HeN mice | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | MAPKs are activated by phosphorylation through MAPK kinases | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
dendritic cell | splenic | Mus musculus | - |
spleen | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | trauma-hemorrhage suppresses MAPK phosphorylation and activation in lipopolysaccharide-unstimulated splenic dendritic cells, in lipopolysaccharide-unstimulated cells the activation is increased, modeling, overview | Mus musculus | ? | - |
? | |
additional information | trauma-hemorrhage suppresses MAPK phosphorylation and activation in lipopolysaccharide-unstimulated splenic dendritic cells, in lipopolysaccharide-unstimulated cells the activation is increased, modelling, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ERK1/2 | - |
Mus musculus |
JNK-1 | - |
Mus musculus |
JNK-2 | - |
Mus musculus |
JNK-3 | - |
Mus musculus |
p38 | - |
Mus musculus |
SAPK/JNK | - |
Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00004 | - |
inhibition of JNK1 | Mus musculus | II/SP600125 | |
0.00004 | - |
inhibition of JNK2 | Mus musculus | II/SP600125 | |
0.00009 | - |
inhibition of JNK3 | Mus musculus | II/SP600125 |