Literature summary for 2.7.11.24 extracted from

ter Haar, E.; Prabhakar, P.; Prabakhar, P.; Liu, X.; Lepre, C.
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer (2007), J. Biol. Chem., 282, 9733-9739.

Search for more literature for 2.7.11.24

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	MKK6-DD phosphorylates the p38a-MK2 heterodimer	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structure of the unphosphorylated p38alpha-MK2, by hanging drop method, full-length p38alpha-MK2 complex to 4 A resolution, belongs to spacegroup P41 with unit cell dimensions of 103.09 A, 103.09 A, 231.42 A, 90.0°, 90.0°, 90.0°, p38alpha-MK2 peptide complex, belongs to spacegroup P31 with unit cell dimensions of 81.55 A, 81.55 A, 121.36 A, 90.0°, 90.0°, 120.0°. C-terminal regulatory domain of MK2 binds in the docking groove of p38alpha, and the ATP-binding sites of both kinases are at the heterodimer interface	Homo sapiens

Crystallization (Comment)

Organism

crystal structure of the unphosphorylated p38alpha-MK2, by hanging drop method, full-length p38alpha-MK2 complex to 4 A resolution, belongs to spacegroup P41 with unit cell dimensions of 103.09 A, 103.09 A, 231.42 A, 90.0°, 90.0°, 90.0°, p38alpha-MK2 peptide complex, belongs to spacegroup P31 with unit cell dimensions of 81.55 A, 81.55 A, 121.36 A, 90.0°, 90.0°, 120.0°. C-terminal regulatory domain of MK2 binds in the docking groove of p38alpha, and the ATP-binding sites of both kinases are at the heterodimer interface

Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
SB203580	inhibits MK2 phosphorylation	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
gel filtration	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + MK2	-	Homo sapiens	ADP + phosphorylated MK2	-	?

Synonyms

Synonyms	Comment	Organism
P38alpha-MAPKAP kinase 2	-	Homo sapiens

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Release 2023.1 (January 2023)