Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Epidermal growth factor | MPK1 is responsive to exogenous host epidermal growth factor, which increases MPK1 phosphorylation | Echinococcus multilocularis | |
hepatocyte | host hepatocytes lead to maximal induction of MPK1 phosphorylation | Echinococcus multilocularis | |
serum | host serum positively effects MPK1 phosphorylation | Echinococcus multilocularis |
Application | Comment | Organism |
---|---|---|
medicine | Echinococcus multilocularis metacestode is able to sense epidermal growth factor from the host which results in an activation of the parasites MAP kinase cascade. MPK1 contains all amino acid residues characteristic for MAP kinases, including a conserved TEY motif which identifies the protein as a member of the ERK subfamily of MAP kinases | Echinococcus multilocularis |
Cloned (Comment) | Organism |
---|---|
entire reading frame encoding MPK1-A cloned into the pBAD adn pBAD/Thio expression system, heterologous expression in Escherichia coli | Echinococcus multilocularis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Echinococcus multilocularis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
42000 | - |
sequence analysis, Western blot analysis | Echinococcus multilocularis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Echinococcus multilocularis | - |
isolate H95 | - |
Purification (Comment) | Organism |
---|---|
- |
Echinococcus multilocularis |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
larva | protein and its phosphorylated form present in the larval stages metacestode and protoscolex during in vitro cultivation and during an infection of the intermediate host | Echinococcus multilocularis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + myelin basic protein | - |
Echinococcus multilocularis | ADP + phosphorylated myelin basic protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAP kinase | - |
Echinococcus multilocularis |
mitogen-activated protein kinase | - |
Echinococcus multilocularis |
MPK1 | - |
Echinococcus multilocularis |