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Literature summary for 2.7.11.24 extracted from

  • Zelck, U.E.; Gege, B.E.; Schmid, S.
    Specific inhibitors of mitogen-activated protein kinase and PI3-K pathways impair immune responses by hemocytes of trematode intermediate host snails (2007), Dev. Comp. Immunol., 31, 321-331.
    View publication on PubMed

Application

Application Comment Organism
additional information MAPK signal transduction pathway plays a pivotal role in the immune responses of snail hemocytes. ERK appears to strongly regulate cell motility. ERK, JNK and p38 contribute to phagocytosis-mediated signal transduction. ERK also plays a major role in oxidative burst activation and the encapsulation of trematode larvae by snail hemocytes Lymnaea stagnalis
additional information MAPK signal transduction pathway plays a pivotal role in the immune responses of snail hemocytes. ERK appears to strongly regulate cell motility. ERK, JNK and p38 contribute to phagocytosis-mediated signal transduction. ERK also plays a major role in oxidative burst activation and the encapsulation of trematode larvae by snail hemocytes Biomphalaria glabrata

Inhibitors

Inhibitors Comment Organism Structure
PD098059 ERK inhibitor, significantly reduces hemocyte spreading in a dose-dependent manner, impairs sheep red blood cell phagocytosis, severely inhibits H2O2 production during phagocytosis, significantly impairs the cellular encapsulation of trematode larvae and H2O2 production during encapsulation Biomphalaria glabrata
PD098059 ERK inhibitor, significantly reduces hemocyte spreading in a dose-dependent manner, impairs sheep red blood cell phagocytosis, severely inhibits H2O2 production during phagocytosis, significantly impairs the cellular encapsulation of trematode larvae and H2O2 production during encapsulation Lymnaea stagnalis
SB203580 p38 kinase inhibitor,has no effect on hemocyte spreading, impairs sheep red blood cell phagocytosis Biomphalaria glabrata
SB203580 p38 kinase inhibitor,has no effect on hemocyte spreading, impairs sheep red blood cell phagocytosis Lymnaea stagnalis
SP600125 JNK inhibitor has no effect on hemocyte spreading, impairs sheep red blood cell phagocytosis Biomphalaria glabrata
SP600125 JNK inhibitor has no effect on hemocyte spreading, impairs sheep red blood cell phagocytosis Lymnaea stagnalis

Organism

Organism UniProt Comment Textmining
Biomphalaria glabrata
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strains 13-16-R1 and M-line
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Lymnaea stagnalis
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-
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Source Tissue

Source Tissue Comment Organism Textmining
hemocyte
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Lymnaea stagnalis
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hemocyte
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Biomphalaria glabrata
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Synonyms

Synonyms Comment Organism
ERK1
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Lymnaea stagnalis
ERK1
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Biomphalaria glabrata
ERK2
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Lymnaea stagnalis
ERK2
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Biomphalaria glabrata
extracellular-signal regulated kinase 1
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Lymnaea stagnalis
extracellular-signal regulated kinase 1
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Biomphalaria glabrata
extracellular-signal regulated kinase 2
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Lymnaea stagnalis
extracellular-signal regulated kinase 2
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Biomphalaria glabrata
JNK
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Lymnaea stagnalis
JNK
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Biomphalaria glabrata
MAPK
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Lymnaea stagnalis
MAPK
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Biomphalaria glabrata
mitogen-activated protein kinase
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Lymnaea stagnalis
mitogen-activated protein kinase
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Biomphalaria glabrata
p38
-
Lymnaea stagnalis
p38
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Biomphalaria glabrata