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Literature summary for 2.7.11.24 extracted from
- Mps1 phosphorylation by MAP kinase is required for kinetochore localization of spindle-checkpoint proteins (2006), Curr. Biol., 16, 1764-1769.
Application
| Application | Comment | Organism |
|---|---|---|
| additional information | increased phosphorylation at M phase is dependent on MAPK, controls several major steps in the spindle checkpoint | Xenopus laevis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| U0126 | MAPK inhibitor, treatment of metaphase egg extracts reduces Mps1 phosphorylation | Xenopus laevis |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| kinetochore | - |
Xenopus laevis | 776 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Xenopus laevis | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| egg | - |
Xenopus laevis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Mps1 | Mps1 phosphorylation by MAPK at S844, spindle checkpoint requires phosphorylation at S844, may create a phosphoepitope that allows Mps1 to interact with kinetochores | Xenopus laevis | ADP + phosphorylated Mps1 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MAP kinase | - |
Xenopus laevis |
| MAPK | - |
Xenopus laevis |
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