Literature summary for 2.7.11.24 extracted from

Uddin, S.; Ah-Kang, J.; Ulaszek, J.; Mahmud, D.; Wickrema, A.
Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells (2004), Proc. Natl. Acad. Sci. USA, 101, 147-152.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	p38 expression and activity in signaling in erythroid cells is independent of erythropoietin	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	phosphorylation of p38alpha occurs in vivo only in absence of growth factor in primary erythroid progenitors	Homo sapiens
SB203580	p38 isozyme alpha-specific inhibitor	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	p38 isozymes are involved in multiple cellular functions such as cell proliferation, cell differentiation, apoptosis, and inflammation response, p38 expression and activity in signaling in erythroid cells is independent of erythropoietin	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	four p38 isoforms alpha-delta	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	p38 isozymes are activated by phosphorylation through MAPK kinases MKK3, MKK6, and MAPKAP-2, EC 2.7.11.25, except for isozyme beta which is not activated by MKK3	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythroid cell	p38 isozymes alpha-delta expression patterns during erythroid differentiation of primary erythroid progenitors, isozymes alpha and gamma are expressed in early hematopoietic progenitors as well as in late differentiating erythroblasts, isozyme delta is only expressed and active during the terminal phase of erythroid differentiation, while isozyme beta is minimally expresses in early CD34+ hematopoietic progenitors	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + protein ATF2	recombinant GST-tagged ATF2 substrate	Homo sapiens	ADP + phosphorylated protein ATF2	-	?
additional information	p38 isozymes are involved in multiple cellular functions such as cell proliferation, cell differentiation, apoptosis, and inflammation response, p38 expression and activity in signaling in erythroid cells is independent of erythropoietin	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
MAP kinase	-	Homo sapiens
MAPK	-	Homo sapiens
mitogen-activated protein kinase	-	Homo sapiens
p38	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
22	-	assay at room temperature	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)