Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glucocorticoids | activate p38 MAPK, e.g. by induction of activating MKK3 | Homo sapiens | |
additional information | p38 MAPk is activated through phosphorylation by MKK3, a MAPK kinase EC 2.7.11.25 | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + human glucocorticoid receptor | Homo sapiens | specific phosphorylation at Ser211 by p38 MAPK, p38 MAPK is a mediator in glucocorticoid-induced apoptosis of lymphoid cells, interaction of MAPK and glucocorticoid pathways, overview | ADP + phosphorylated human glucocorticoid receptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme p38alpha MAPK | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | p38 MAPK is activated through phosphorylation by MKK3, a MAPK kinase EC 2.7.11.25 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CCRF-CEM cell | cell line of a human with lymphoblastic leukemia | Homo sapiens | - |
lymphoid cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + human glucocorticoid receptor | specific phosphorylation at Ser211 by p38 MAPK, p38 MAPK is a mediator in glucocorticoid-induced apoptosis of lymphoid cells, interaction of MAPK and glucocorticoid pathways, overview | Homo sapiens | ADP + phosphorylated human glucocorticoid receptor | - |
? | |
ATP + human glucocorticoid receptor | specific phosphorylation at Ser211 by p38 MAPK | Homo sapiens | ADP + phosphorylated human glucocorticoid receptor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
p38 MAPK | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |