Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.24 extracted from

  • Ravingerova, T.; Barancik, M.; Strniskova, M.
    Mitogen-activated protein kinases: a new therapeutic target in cardiac pathology (2003), Mol. Cell. Biochem., 247, 127-138.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information MAPKs are activated by phosphorxylation through MEK/MAPK kinases Mus musculus
additional information MAPKs are activated by phosphorxylation through MEK/MAPK kinases Homo sapiens
additional information MAPKs are activated by phosphorxylation through MEK/MAPK kinases Rattus norvegicus
additional information MAPKs are activated by phosphorxylation through MEK/MAPK kinases Sus scrofa
additional information MAPKs are activated by phosphorxylation through MEK/MAPK kinases Oryctolagus cuniculus
additional information MAPKs are activated by phosphorxylation through MEK/MAPK kinases Canis lupus familiaris

Application

Application Comment Organism
drug development MAPKs are targets for drug development Mus musculus
drug development MAPKs are targets for drug development Homo sapiens
drug development MAPKs are targets for drug development Rattus norvegicus
drug development MAPKs are targets for drug development Sus scrofa
drug development MAPKs are targets for drug development Oryctolagus cuniculus
drug development MAPKs are targets for drug development Canis lupus familiaris
medicine MAPKs are therapeutic targets in cardiac pathology Homo sapiens
pharmacology MAPKs are targets for inhibitors and pharmacological drug development Mus musculus
pharmacology MAPKs are targets for inhibitors and pharmacological drug development Homo sapiens
pharmacology MAPKs are targets for inhibitors and pharmacological drug development Rattus norvegicus
pharmacology MAPKs are targets for inhibitors and pharmacological drug development Sus scrofa
pharmacology MAPKs are targets for inhibitors and pharmacological drug development Oryctolagus cuniculus
pharmacology MAPKs are targets for inhibitors and pharmacological drug development Canis lupus familiaris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, aas well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview ?
-
?
additional information Rattus norvegicus signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, aas well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview ?
-
?
additional information Mus musculus signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview ?
-
?
additional information Sus scrofa signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview ?
-
?
additional information Oryctolagus cuniculus signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview ?
-
?
additional information Canis lupus familiaris signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the MAPKs are activated by phosphorylation through MAPK kinases, overview Mus musculus
phosphoprotein the MAPKs are activated by phosphorylation through MAPK kinases, overview Homo sapiens
phosphoprotein the MAPKs are activated by phosphorylation through MAPK kinases, overview Rattus norvegicus
phosphoprotein the MAPKs are activated by phosphorylation through MAPK kinases, overview Sus scrofa
phosphoprotein the MAPKs are activated by phosphorylation through MAPK kinases, overview Oryctolagus cuniculus
phosphoprotein the MAPKs are activated by phosphorylation through MAPK kinases, overview Canis lupus familiaris

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Mus musculus
-
heart
-
Homo sapiens
-
heart
-
Rattus norvegicus
-
heart
-
Sus scrofa
-
heart
-
Oryctolagus cuniculus
-
heart
-
Canis lupus familiaris
-
myocardium the MAPK family enzymes have regulatory function in the myocardium Mus musculus
-
myocardium the MAPK family enzymes have regulatory function in the myocardium Homo sapiens
-
myocardium the MAPK family enzymes have regulatory function in the myocardium Rattus norvegicus
-
myocardium the MAPK family enzymes have regulatory function in the myocardium Sus scrofa
-
myocardium the MAPK family enzymes have regulatory function in the myocardium Oryctolagus cuniculus
-
myocardium the MAPK family enzymes have regulatory function in the myocardium Canis lupus familiaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, aas well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview Homo sapiens ?
-
?
additional information signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, aas well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview Rattus norvegicus ?
-
?
additional information signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview Mus musculus ?
-
?
additional information signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview Sus scrofa ?
-
?
additional information signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview Oryctolagus cuniculus ?
-
?
additional information signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview Canis lupus familiaris ?
-
?

Synonyms

Synonyms Comment Organism
ERK1
-
Mus musculus
ERK1
-
Homo sapiens
ERK1
-
Rattus norvegicus
ERK1
-
Sus scrofa
ERK1
-
Oryctolagus cuniculus
ERK1
-
Canis lupus familiaris
ERK2
-
Mus musculus
ERK2
-
Homo sapiens
ERK2
-
Rattus norvegicus
ERK2
-
Sus scrofa
ERK2
-
Oryctolagus cuniculus
ERK2
-
Canis lupus familiaris
JNK
-
Mus musculus
JNK
-
Homo sapiens
JNK
-
Rattus norvegicus
JNK
-
Sus scrofa
JNK
-
Oryctolagus cuniculus
JNK
-
Canis lupus familiaris
MAPK
-
Mus musculus
MAPK
-
Homo sapiens
MAPK
-
Rattus norvegicus
MAPK
-
Sus scrofa
MAPK
-
Oryctolagus cuniculus
MAPK
-
Canis lupus familiaris
More the enzyme belongs to the MAPK superfamily of enzymes Mus musculus
More the enzyme belongs to the MAPK superfamily of enzymes Homo sapiens
More the enzyme belongs to the MAPK superfamily of enzymes Rattus norvegicus
More the enzyme belongs to the MAPK superfamily of enzymes Sus scrofa
More the enzyme belongs to the MAPK superfamily of enzymes Oryctolagus cuniculus
More the enzyme belongs to the MAPK superfamily of enzymes Canis lupus familiaris
p38-MAPK
-
Mus musculus
p38-MAPK
-
Homo sapiens
p38-MAPK
-
Rattus norvegicus
p38-MAPK
-
Sus scrofa
p38-MAPK
-
Oryctolagus cuniculus
p38-MAPK
-
Canis lupus familiaris
SAPK
-
Mus musculus
SAPK
-
Homo sapiens
SAPK
-
Rattus norvegicus
SAPK
-
Sus scrofa
SAPK
-
Oryctolagus cuniculus
SAPK
-
Canis lupus familiaris

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus
ATP
-
Homo sapiens
ATP
-
Rattus norvegicus
ATP
-
Sus scrofa
ATP
-
Oryctolagus cuniculus
ATP
-
Canis lupus familiaris