Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | MAPKs are activated by phosphorxylation through MEK/MAPK kinases | Mus musculus | |
additional information | MAPKs are activated by phosphorxylation through MEK/MAPK kinases | Homo sapiens | |
additional information | MAPKs are activated by phosphorxylation through MEK/MAPK kinases | Rattus norvegicus | |
additional information | MAPKs are activated by phosphorxylation through MEK/MAPK kinases | Sus scrofa | |
additional information | MAPKs are activated by phosphorxylation through MEK/MAPK kinases | Oryctolagus cuniculus | |
additional information | MAPKs are activated by phosphorxylation through MEK/MAPK kinases | Canis lupus familiaris |
Application | Comment | Organism |
---|---|---|
drug development | MAPKs are targets for drug development | Mus musculus |
drug development | MAPKs are targets for drug development | Homo sapiens |
drug development | MAPKs are targets for drug development | Rattus norvegicus |
drug development | MAPKs are targets for drug development | Sus scrofa |
drug development | MAPKs are targets for drug development | Oryctolagus cuniculus |
drug development | MAPKs are targets for drug development | Canis lupus familiaris |
medicine | MAPKs are therapeutic targets in cardiac pathology | Homo sapiens |
pharmacology | MAPKs are targets for inhibitors and pharmacological drug development | Mus musculus |
pharmacology | MAPKs are targets for inhibitors and pharmacological drug development | Homo sapiens |
pharmacology | MAPKs are targets for inhibitors and pharmacological drug development | Rattus norvegicus |
pharmacology | MAPKs are targets for inhibitors and pharmacological drug development | Sus scrofa |
pharmacology | MAPKs are targets for inhibitors and pharmacological drug development | Oryctolagus cuniculus |
pharmacology | MAPKs are targets for inhibitors and pharmacological drug development | Canis lupus familiaris |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, aas well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview | ? | - |
? | |
additional information | Rattus norvegicus | signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, aas well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview | ? | - |
? | |
additional information | Mus musculus | signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview | ? | - |
? | |
additional information | Sus scrofa | signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview | ? | - |
? | |
additional information | Oryctolagus cuniculus | signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview | ? | - |
? | |
additional information | Canis lupus familiaris | signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the MAPKs are activated by phosphorylation through MAPK kinases, overview | Mus musculus |
phosphoprotein | the MAPKs are activated by phosphorylation through MAPK kinases, overview | Homo sapiens |
phosphoprotein | the MAPKs are activated by phosphorylation through MAPK kinases, overview | Rattus norvegicus |
phosphoprotein | the MAPKs are activated by phosphorylation through MAPK kinases, overview | Sus scrofa |
phosphoprotein | the MAPKs are activated by phosphorylation through MAPK kinases, overview | Oryctolagus cuniculus |
phosphoprotein | the MAPKs are activated by phosphorylation through MAPK kinases, overview | Canis lupus familiaris |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Mus musculus | - |
heart | - |
Homo sapiens | - |
heart | - |
Rattus norvegicus | - |
heart | - |
Sus scrofa | - |
heart | - |
Oryctolagus cuniculus | - |
heart | - |
Canis lupus familiaris | - |
myocardium | the MAPK family enzymes have regulatory function in the myocardium | Mus musculus | - |
myocardium | the MAPK family enzymes have regulatory function in the myocardium | Homo sapiens | - |
myocardium | the MAPK family enzymes have regulatory function in the myocardium | Rattus norvegicus | - |
myocardium | the MAPK family enzymes have regulatory function in the myocardium | Sus scrofa | - |
myocardium | the MAPK family enzymes have regulatory function in the myocardium | Oryctolagus cuniculus | - |
myocardium | the MAPK family enzymes have regulatory function in the myocardium | Canis lupus familiaris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, aas well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview | Homo sapiens | ? | - |
? | |
additional information | signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, aas well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview | Rattus norvegicus | ? | - |
? | |
additional information | signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview | Mus musculus | ? | - |
? | |
additional information | signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview | Sus scrofa | ? | - |
? | |
additional information | signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview | Oryctolagus cuniculus | ? | - |
? | |
additional information | signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, as well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview | Canis lupus familiaris | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ERK1 | - |
Mus musculus |
ERK1 | - |
Homo sapiens |
ERK1 | - |
Rattus norvegicus |
ERK1 | - |
Sus scrofa |
ERK1 | - |
Oryctolagus cuniculus |
ERK1 | - |
Canis lupus familiaris |
ERK2 | - |
Mus musculus |
ERK2 | - |
Homo sapiens |
ERK2 | - |
Rattus norvegicus |
ERK2 | - |
Sus scrofa |
ERK2 | - |
Oryctolagus cuniculus |
ERK2 | - |
Canis lupus familiaris |
JNK | - |
Mus musculus |
JNK | - |
Homo sapiens |
JNK | - |
Rattus norvegicus |
JNK | - |
Sus scrofa |
JNK | - |
Oryctolagus cuniculus |
JNK | - |
Canis lupus familiaris |
MAPK | - |
Mus musculus |
MAPK | - |
Homo sapiens |
MAPK | - |
Rattus norvegicus |
MAPK | - |
Sus scrofa |
MAPK | - |
Oryctolagus cuniculus |
MAPK | - |
Canis lupus familiaris |
More | the enzyme belongs to the MAPK superfamily of enzymes | Mus musculus |
More | the enzyme belongs to the MAPK superfamily of enzymes | Homo sapiens |
More | the enzyme belongs to the MAPK superfamily of enzymes | Rattus norvegicus |
More | the enzyme belongs to the MAPK superfamily of enzymes | Sus scrofa |
More | the enzyme belongs to the MAPK superfamily of enzymes | Oryctolagus cuniculus |
More | the enzyme belongs to the MAPK superfamily of enzymes | Canis lupus familiaris |
p38-MAPK | - |
Mus musculus |
p38-MAPK | - |
Homo sapiens |
p38-MAPK | - |
Rattus norvegicus |
p38-MAPK | - |
Sus scrofa |
p38-MAPK | - |
Oryctolagus cuniculus |
p38-MAPK | - |
Canis lupus familiaris |
SAPK | - |
Mus musculus |
SAPK | - |
Homo sapiens |
SAPK | - |
Rattus norvegicus |
SAPK | - |
Sus scrofa |
SAPK | - |
Oryctolagus cuniculus |
SAPK | - |
Canis lupus familiaris |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus | |
ATP | - |
Sus scrofa | |
ATP | - |
Oryctolagus cuniculus | |
ATP | - |
Canis lupus familiaris |