Activating Compound | Comment | Organism | Structure |
---|---|---|---|
beta-phorbol-13-acetate | stimulates SERT phosphorylation | Rattus norvegicus | |
D-amphetamine | stimulates SERT phosphorylation | Rattus norvegicus | |
additional information | p38 MAPK needs to be activated by phosphorylation | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expression of p38 MAPK in HEK293 cells | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PD169316 | i.e. 4-(4-fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole, a specific p38 MAPK inhibitor, reduces 5-hydroxytryptamine uptake in cells, inhibits SERT phosphorylation | Rattus norvegicus | |
SB203580 | i.e. 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole, a specific p38 MAPK inhibitor, reduces 5-hydroxytryptamine uptake in cells, inhibits SERT phosphorylation | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
synaptosome | from midbrain | Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | p38 MAPK, but not ERKs or JNKs, regulates the serotonin transporter, SERT, and subsequent signaling induced by 5-hydroxytryptamine, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | p38 MAPK needs to be activated by phosphorylation | Rattus norvegicus |
Purification (Comment) | Organism |
---|---|
purification of synaptosomes | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | p38 MAPK, but not ERKs or JNKs, regulates the serotonin transporter, SERT, and subsequent signaling induced by 5-hydroxytryptamine, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
p38 MAPK | - |
Rattus norvegicus |
p38 mitogen-activated protein kinase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |