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Literature summary for 2.7.11.24 extracted from

  • Buckley, C.T.; Sekiya, F.; Kim, Y.J.; Rhee, S.G.; Caldwell, K.K.
    Identification of phospholipase C-gamma1 as a mitogen-activated protein kinase substrate (2004), J. Biol. Chem., 279, 41807-41814.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information in vitro the recombinant phospholipase C-gamma1 activity is not inhibited by phosphorylation through activated ERK2 Rattus norvegicus
phospholipase C-gamma1 D-domain a peptide containing the phospholipase C-gamma1 D-domain competitively inhibits the phosphorylation of Elk1 and c-Jun by ERK2, overview; a peptide containing the phospholipase C-gamma1 D-domain competitively inhibits the phosphorylation of Elk1 and c-Jun by JNK3, overview Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + c-Jun Rattus norvegicus the reaction is performed by activated phosphorylated ERK2 ADP + phosphorylated c-Jun
-
?
ATP + c-Jun Rattus norvegicus the reaction is performed by activated phosphorylated JNK3 ADP + phosphorylated c-Jun
-
?
ATP + Elk1 Rattus norvegicus the reaction is performed by activated phosphorylated ERK2 ADP + phosphorylated Elk1
-
?
ATP + Elk1 Rattus norvegicus the reaction is performed by activated phosphorylated JNK3 ADP + phosphorylated Elk1
-
?
ATP + phospholipase C-gamma1 Rattus norvegicus the reaction is performed by activated phosphorylated ERK2, phosphorylation inhibits phospholipase C-gamma1 ADP + phosphorylated phospholipase C-gamma1
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Sprague-Dawley rats
-
Rattus norvegicus P63086 ERK2; Sprague-Dawley rats
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein ERK2 is activated by phosphorylation Rattus norvegicus
phosphoprotein JNK3 is activated by phosphorylation Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
hippocampus
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + c-Jun the reaction is performed by activated phosphorylated ERK2 Rattus norvegicus ADP + phosphorylated c-Jun
-
?
ATP + c-Jun the reaction is performed by activated phosphorylated JNK3 Rattus norvegicus ADP + phosphorylated c-Jun
-
?
ATP + c-Jun recombinant GST-tagged substrate, the reaction is performed by activated phosphorylated ERK2 Rattus norvegicus ADP + phosphorylated c-Jun
-
?
ATP + c-Jun recombinant GST-tagged substrate, the reaction is performed by activated phosphorylated JNK3 Rattus norvegicus ADP + phosphorylated c-Jun
-
?
ATP + Elk1 the reaction is performed by activated phosphorylated ERK2 Rattus norvegicus ADP + phosphorylated Elk1
-
?
ATP + Elk1 the reaction is performed by activated phosphorylated JNK3 Rattus norvegicus ADP + phosphorylated Elk1
-
?
ATP + Elk1 recombinant GST-tagged substrate, the reaction is performed by activated phosphorylated ERK2 Rattus norvegicus ADP + phosphorylated Elk1
-
?
ATP + Elk1 recombinant GST-tagged substrate, the reaction is performed by activated phosphorylated JNK3 Rattus norvegicus ADP + phosphorylated Elk1
-
?
ATP + phospholipase C-gamma1 the reaction is performed by activated phosphorylated ERK2, phosphorylation inhibits phospholipase C-gamma1 Rattus norvegicus ADP + phosphorylated phospholipase C-gamma1
-
?
ATP + phospholipase C-gamma1 recombinant substrate, the reaction is performed by activated phosphorylated ERK2 Rattus norvegicus ADP + phosphorylated phospholipase C-gamma1
-
?
additional information MAPK phosphorylation consensus sequences Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
c-Jun N-terminal kinase 3
-
Rattus norvegicus
ERK2
-
Rattus norvegicus
extracellular signal-regulated kinase 2
-
Rattus norvegicus
JNK3
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus