Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | in vitro the recombinant phospholipase C-gamma1 activity is not inhibited by phosphorylation through activated ERK2 | Rattus norvegicus | |
phospholipase C-gamma1 D-domain | a peptide containing the phospholipase C-gamma1 D-domain competitively inhibits the phosphorylation of Elk1 and c-Jun by ERK2, overview; a peptide containing the phospholipase C-gamma1 D-domain competitively inhibits the phosphorylation of Elk1 and c-Jun by JNK3, overview | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + c-Jun | Rattus norvegicus | the reaction is performed by activated phosphorylated ERK2 | ADP + phosphorylated c-Jun | - |
? | |
ATP + c-Jun | Rattus norvegicus | the reaction is performed by activated phosphorylated JNK3 | ADP + phosphorylated c-Jun | - |
? | |
ATP + Elk1 | Rattus norvegicus | the reaction is performed by activated phosphorylated ERK2 | ADP + phosphorylated Elk1 | - |
? | |
ATP + Elk1 | Rattus norvegicus | the reaction is performed by activated phosphorylated JNK3 | ADP + phosphorylated Elk1 | - |
? | |
ATP + phospholipase C-gamma1 | Rattus norvegicus | the reaction is performed by activated phosphorylated ERK2, phosphorylation inhibits phospholipase C-gamma1 | ADP + phosphorylated phospholipase C-gamma1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sprague-Dawley rats | - |
Rattus norvegicus | P63086 | ERK2; Sprague-Dawley rats | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | ERK2 is activated by phosphorylation | Rattus norvegicus |
phosphoprotein | JNK3 is activated by phosphorylation | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
hippocampus | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + c-Jun | the reaction is performed by activated phosphorylated ERK2 | Rattus norvegicus | ADP + phosphorylated c-Jun | - |
? | |
ATP + c-Jun | the reaction is performed by activated phosphorylated JNK3 | Rattus norvegicus | ADP + phosphorylated c-Jun | - |
? | |
ATP + c-Jun | recombinant GST-tagged substrate, the reaction is performed by activated phosphorylated ERK2 | Rattus norvegicus | ADP + phosphorylated c-Jun | - |
? | |
ATP + c-Jun | recombinant GST-tagged substrate, the reaction is performed by activated phosphorylated JNK3 | Rattus norvegicus | ADP + phosphorylated c-Jun | - |
? | |
ATP + Elk1 | the reaction is performed by activated phosphorylated ERK2 | Rattus norvegicus | ADP + phosphorylated Elk1 | - |
? | |
ATP + Elk1 | the reaction is performed by activated phosphorylated JNK3 | Rattus norvegicus | ADP + phosphorylated Elk1 | - |
? | |
ATP + Elk1 | recombinant GST-tagged substrate, the reaction is performed by activated phosphorylated ERK2 | Rattus norvegicus | ADP + phosphorylated Elk1 | - |
? | |
ATP + Elk1 | recombinant GST-tagged substrate, the reaction is performed by activated phosphorylated JNK3 | Rattus norvegicus | ADP + phosphorylated Elk1 | - |
? | |
ATP + phospholipase C-gamma1 | the reaction is performed by activated phosphorylated ERK2, phosphorylation inhibits phospholipase C-gamma1 | Rattus norvegicus | ADP + phosphorylated phospholipase C-gamma1 | - |
? | |
ATP + phospholipase C-gamma1 | recombinant substrate, the reaction is performed by activated phosphorylated ERK2 | Rattus norvegicus | ADP + phosphorylated phospholipase C-gamma1 | - |
? | |
additional information | MAPK phosphorylation consensus sequences | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
c-Jun N-terminal kinase 3 | - |
Rattus norvegicus |
ERK2 | - |
Rattus norvegicus |
extracellular signal-regulated kinase 2 | - |
Rattus norvegicus |
JNK3 | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |