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Literature summary for 2.7.11.24 extracted from

  • Pelaia, G.; Cuda, G.; Vatrella, A.; Fratto, D.; Tagliaferri, P.; Maselli, R.; Costanzo, F.S.; Marsico, S.A.
    Mitogen-activated protein kinases: new molecular targets for pharmacological treatment of inflammatory lung diseases (2003), Curr. Med. Chem., 2, 131-141.
No PubMed abstract available
Search for more literature for 2.7.11.24

Activating Compound

Activating Compound Comment Organism Structure
interleukin-1beta activates the MAPKs, dexamethasone inhibits this activation Homo sapiens
additional information oxidative stress activates the MAPKs, dexamethasone inhibits this activation Homo sapiens
TNF-alpha activates the MAPKs, dexamethasone inhibits this activation Homo sapiens
transforming growth factor-beta i.e. TGF-beta, activates p38, butenoside inhibits this activation Homo sapiens

Application

Application Comment Organism
medicine MAPKs are a molecular targets for pharmacological treatment of inflammatory lung diseases Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens MAPKs, e.g. p38, play a key role in the transductin of biological signals from cell surface receptors, through the cytoplasm, to the transcriptional machinery in the nucleus ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bronchus primary epithelial cells Homo sapiens
-
endothelial cell
-
 Homo sapiens
-
epithelial cell primary Homo sapiens
-
vascular endothelial cell of airway and alveolar endothelium Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information MAPKs, e.g. p38, play a key role in the transductin of biological signals from cell surface receptors, through the cytoplasm, to the transcriptional machinery in the nucleus Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
p38
-
 Homo sapiens