Literature summary for 2.7.11.24 extracted from

Hofmann, M.; Zaper, J.; Bernd, A.; Bereiter-Hahn, J.; Kaufmann, R.; Kippenberger, S.
Mechanical pressure-induced phosphorylation of p38 mitogen-activated protein kinase in epithelial cells via Src and protein kinase C (2004), Biochem. Biophys. Res. Commun., 316, 673-679.

Search for more literature for 2.7.11.24

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	p38 is activated by phosphorylation through kinase Src, EC 2.7.10.2, mechanical pressure on the cell induces p38alpha and beta isozyme phosphorylation, which is suppressed by PKC isozymes, EC 2.7.11.13	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	PKC isozymes, EC 2.7.11.13, suppress p38 activating phosphorylation under mechanical pressure of cells	Homo sapiens
SB202190	i.e. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, a specific p38beta isozyme inhibitor	Homo sapiens
SB203580	i.e. 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, a specific p38alpha isozyme inhibitor	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isozymes p38alpha and p38beta	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	p38alpha is activated by phosphorylation at Thr180/Tyr182 by kinase Src, EC 2.7.10.2, mechanical pressure on the cell induces p38 phosphorylation, which is suppressed by PKC isozymes, EC 2.7.11.13	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
epithelial cell	-	Homo sapiens	-
HaCaT cell	spontaneously immortalized keratinocyte cell line	Homo sapiens	-
keratinocyte	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
p38	-	Homo sapiens
p38 mitogen-activated protein kinase	-	Homo sapiens

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Release 2023.1 (January 2023)