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Literature summary for 2.7.11.24 extracted from

  • Schwartz, M.A.; Madhani, H.D.
    Principles of MAP kinase signaling specificity in Saccharomyces cerevisiae (2004), Annu. Rev. Genet., 38, 725-748.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information pheromones can influence the phosphorylation of MAPKs, the scaffolding proteins Ste mediate MAPK function in signaling by recruitment of the kinases to reaction sites, e.g. the plasma membrane, or by concentrating and maybe also by orientating relevant reaction components, e.g. Ste5, overview Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
additional information pheromones can influence the phosphorylation of MAPKs Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information signaling kinetics, overview Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae Fus3, Kss1, and Hog1 function during the mating pheromone response, the switch of filamentous growth, and the response to high osmolarity, respectively, detailed pathway overview, MAPK signaling pathways and specificity, pathway sequestering mechanism modeling, separation via subcellular compartmentalization, temporal separation, scaffolding, combinatorial signaling, detailed overview ?
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?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
encodes 6 MAPK orthologues
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein MAPKs are specifically activated by phosphorylation through specific MAPK kinases, EC 2.7.11.25, Fus3 is phosphorylated at 2 sites and activated by scaffolding protein Ste11, pheromones can influence the phosphorylation of MAPKs Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Fus3, Kss1, and Hog1 function during the mating pheromone response, the switch of filamentous growth, and the response to high osmolarity, respectively, detailed pathway overview, MAPK signaling pathways and specificity, pathway sequestering mechanism modeling, separation via subcellular compartmentalization, temporal separation, scaffolding, combinatorial signaling, detailed overview Saccharomyces cerevisiae ?
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?

Synonyms

Synonyms Comment Organism
Fus3
-
Saccharomyces cerevisiae
Hog1
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Saccharomyces cerevisiae
Kss1
-
Saccharomyces cerevisiae
MAP kinase
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Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
-
Saccharomyces cerevisiae