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Literature summary for 2.7.11.24 extracted from

  • Werry, T.D.; Gregory, K.J.; Sexton, P.M.; Christopoulos, A.
    Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2 (2005), J. Neurochem., 93, 1603-1615.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information ERK phosphorylation activates the enzyme activity, stimulation by 7TMD receptors, e.g. the serotonin 5-HT2c receptor Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of ERK in CHO cells, co-expression of serotonin 5-HT2c receptor leads to increased ERK phosphorylation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Homo sapiens
-
 ADP + a phosphoprotein
-
 ?
additional information Homo sapiens signaling pathway, including ERK, regulation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein ERKs are phosphorylated, involving protein kinase C and phospholipase D, in signaling pathways by kinases, which are stimulated by the serotonin 5-HT2c receptor, ERK phosphorylation activates its enzyme activity, overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Homo sapiens ADP + a phosphoprotein
-
 ?
additional information signaling pathway, including ERK, regulation, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ERK1
-
 Homo sapiens
ERK2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens