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Literature summary for 2.7.11.24 extracted from

  • Goedert, M.; Cuenda, A.; Craxton, M.; Jakes, R.; Cohen, P.
    Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases (1997), EMBO J., 16, 3563-3571.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.24

Activating Compound

Activating Compound Comment Organism Structure
cytokines
-
 Homo sapiens
MKK6 activates Homo sapiens
additional information
-
 Homo sapiens
additional information when expressed in KB cells, SAPK4 is activated in response to cellular stresses and pro-inflammatory cytokines Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by the drugs SB 203580 and SB 202190 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O15264
-
-
Homo sapiens Q15759
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + MAPKAP kinase-2
-
 Homo sapiens ADP + phosphorylated MAPKAP kinase-2
-
 ?
ATP + MAPKAP kinase-3
-
 Homo sapiens ADP + phosphorylated MAPKAP kinase-3
-
 ?
ATP + transcription factor ATF2
-
 Homo sapiens ADP + phosphorylated transcription factor ATF2
-
 ?
ATP + transcription factor Elk-1
-
 Homo sapiens ADP + phosphorylated transcription factor Elk-1
-
 ?
ATP + transcription factor SAP-1
-
 Homo sapiens ADP + phosphorylated transcription factor SAP-1
-
 ?
additional information no phosphorylation of the activation domain of c-Jun Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
mitogen-activated protein kinase 11
-
 Homo sapiens
mitogen-activated protein kinase 13
-
 Homo sapiens
stress-activated protein kinase-4
-
 Homo sapiens