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Literature summary for 2.7.11.24 extracted from
- Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines (1999), J. Biol. Chem., 274, 7095-7102.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | p38-delta is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7, suggesting that p38-delta is a unique stress-responsive protein kinase | ? | - |
? |  |
| additional information | Homo sapiens | the enzyme plays a crucial role in stress and inflammatory responses and is also involved in activation of the human immunodeficiency virus gene expression | ? | - |
? | |
| additional information | Rattus norvegicus | the enzyme plays a crucial role in stress and inflammatory responses and is also involved in activation of the human immunodeficiency virus gene expression | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O15264 | - |
- |
| Rattus norvegicus | Q9WTY9 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | p38-delta is expressed predominantly in the developing gut and the septum transversum in the mouse embryo at 9.5 days, its expression begins to be expanded to many specific tissues in the 12.5-day embryo. At 15.5 days, p38-delta is expressed virtually in most developing epithelia in embryos | Rattus norvegicus | - |
| endothelial cell | - |
Rattus norvegicus | - |
| gut epithelium | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| testis | - |
Homo sapiens | - |
| testis | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | p38-delta is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7, suggesting that p38-delta is a unique stress-responsive protein kinase | Rattus norvegicus | ? | - |
? | |
| additional information | the enzyme plays a crucial role in stress and inflammatory responses and is also involved in activation of the human immunodeficiency virus gene expression | Homo sapiens | ? | - |
? | |
| additional information | the enzyme plays a crucial role in stress and inflammatory responses and is also involved in activation of the human immunodeficiency virus gene expression | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| mitogen-activated protein kinase 13 | - |
Homo sapiens |
| mitogen-activated protein kinase 13 | - |
Rattus norvegicus |
| p38 mitogen-activated protein kinase | - |
Homo sapiens |
| p38 mitogen-activated protein kinase | - |
Rattus norvegicus |
| p38-delta mitogen-activated protein kinase | - |
Homo sapiens |
| p38-delta mitogen-activated protein kinase | - |
Rattus norvegicus |
| p38delta | - |
Homo sapiens |
| p38delta | - |
Rattus norvegicus |
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