Literature summary for 2.7.11.23 extracted from

Narita, T.; Ishida, T.; Ito, A.; Masaki, A.; Kinoshita, S.; Suzuki, S.; Takino, H.; Yoshida, T.; Ri, M.; Kusumoto, S.; Komatsu, H.; Imada, K.; Tanaka, Y.; Takaori-Kondo, A.; Inagaki, H.; Scholz, A.; Lienau, P.; Kuroda, T.; Ueda, R.; Iida, S.
Cyclin-dependent kinase 9 is a novel specific molecular target in adult T-cell leukemia/lymphoma (2017), Blood, 130, 1114-1124 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
BAY 1143572	novel and highly selective CDK9/P-TEFb inhibitor	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [RNA polymerase II]	Mus musculus	cyclin-dependent kinase 9 (CDK9) is a subunit of the positive transcription elongation factor b (P-TEFb) complex that regulates gene transcription elongation by phosphorylating the C-terminal domain (CTD) of RNA polymerase II	ADP + phospho-[RNA polymerase II]	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q99J95	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [RNA polymerase II]	-	Mus musculus	ADP + phospho-[RNA polymerase II]	-	?
ATP + [RNA polymerase II]	cyclin-dependent kinase 9 (CDK9) is a subunit of the positive transcription elongation factor b (P-TEFb) complex that regulates gene transcription elongation by phosphorylating the C-terminal domain (CTD) of RNA polymerase II	Mus musculus	ADP + phospho-[RNA polymerase II]	-	?

Synonyms

Synonyms	Comment	Organism
CDK9	-	Mus musculus
cyclin-dependent kinase 9	-	Mus musculus

General Information

General Information	Comment	Organism
drug target	the highly selective CDK9/P-TEFb inhibitor BAY1143572 shows strong potential as a treatment of adult T-cell leukemia/lymphoma (ATL)	Mus musculus
malfunction	the deregulation of CDK9/PTEFb has important implications for many cancer types	Mus musculus
metabolism	cyclin-dependent kinase 9 (CDK9) is a subunit of the positive transcription elongation factor b (P-TEFb) complex that regulates gene transcription elongation by phosphorylating the C-terminal domain (CTD) of RNA polymerase II	Mus musculus

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Release 2023.1 (January 2023)