Protein Variants | Comment | Organism |
---|---|---|
additional information | a temperature-sensitive mutant and the analog-sensitive mutant of Kin28 is that upon heat inactivation, Kin28ts alleles are unable to retain protein interactions with other subunits of the TFIIH complex | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-NA-PP1 | potent inhibitor of Kin28as allele kinase activity, Kin28as inhibition reduces transcript capping, overview, but inhibition of Kin28 does not inhibit transcription | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + RNA polymerase II C-terminal domain | Saccharomyces cerevisiae | TFIIH, a 10-subunit complex with many resident enzymatic activities, is essential for transcription by RNA polymerase II involving the TFIIH-associated kinase, Cdk7, which phosphorylates the C-terminal domain, CTD, of Rpb1, the largest subunit of Pol II | ADP + phosphoylated RNA polymerase II C-terminal subunit | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + RNA polymerase II C-terminal domain | TFIIH, a 10-subunit complex with many resident enzymatic activities, is essential for transcription by RNA polymerase II involving the TFIIH-associated kinase, Cdk7, which phosphorylates the C-terminal domain, CTD, of Rpb1, the largest subunit of Pol II | Saccharomyces cerevisiae | ADP + phosphoylated RNA polymerase II C-terminal subunit | - |
? | |
ATP + RNA polymerase II C-terminal domain | Cdk7 phosphorylates the C-terminal domain, CTD, that consists of multiple YSPTSPS heptapeptide repeats, at Ser5 | Saccharomyces cerevisiae | ADP + phosphoylated RNA polymerase II C-terminal subunit | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cdk7 | - |
Saccharomyces cerevisiae |
Cdk7/Kin28 | - |
Saccharomyces cerevisiae |
Kin28 | - |
Saccharomyces cerevisiae |
TFIIH | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Saccharomyces cerevisiae |