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Literature summary for 2.7.11.23 extracted from

  • Ni, Z.; Saunders, A.; Fuda, N.J.; Yao, J.; Suarez, J.R.; Webb, W.W.; Lis, J.T.
    P-TEFb is critical for the maturation of RNA polymerase II into productive elongation in vivo (2008), Mol. Cell. Biol., 28, 1161-1170.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.23

Inhibitors

Inhibitors Comment Organism Structure
additional information enzyme inhibition affects the binding of Hsp70 to RNA polymerase II, overview Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + RNA polymerase II C-terminal subunit Drosophila melanogaster Positive transcription elongation factor b is the major metazoan RNA polymerase II carboxyl-terminal domain Ser2 kinase, P-TEFb is critical for the maturation of RNA PolII into productive elongation in vivo, overview ADP + phosphoylated RNA polymerase II C-terminal subunit
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 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
Kc cell
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RNA polymerase II C-terminal subunit Positive transcription elongation factor b is the major metazoan RNA polymerase II carboxyl-terminal domain Ser2 kinase, P-TEFb is critical for the maturation of RNA PolII into productive elongation in vivo, overview Drosophila melanogaster ADP + phosphoylated RNA polymerase II C-terminal subunit
-
 ?
ATP + RNA polymerase II C-terminal subunit phosphorylation of Ser2 Drosophila melanogaster ADP + phosphoylated RNA polymerase II C-terminal subunit
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 ?

Synonyms

Synonyms Comment Organism
P-TEFb
-
 Drosophila melanogaster
Pol II CTD Ser2 kinase
-
 Drosophila melanogaster
positive transcription elongation factor b
-
 Drosophila melanogaster
RNA polymerase II carboxyl-terminal domain Ser2 kinase
-
 Drosophila melanogaster

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Drosophila melanogaster