Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.23 extracted from

  • Bres, V.; Yoh, S.M.; Jones, K.A.
    The multi-tasking P-TEFb complex (2008), Curr. Opin. Cell Biol., 20, 334-340.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.23

Activating Compound

Activating Compound Comment Organism Structure
additional information binding of Spt6 to the P-TEFb/Ser2P CTD stimulates the kinetics of mRNA export. Because P-TEFb counteracts NELF- and DSIF-induced pausing in cell-free transcription reactions, at least part of its activity does not depend upon chromatin Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + RNA polymerase II C-terminal subunit Saccharomyces cerevisiae the enzyme regulates transcription elongation at many genes and integrates mRNA synthesis with histone modification, pre-mRNA processing, and mRNA export. Recruitment of P-TEFb to target genes requires deubiquitination of H2Bub, phosphorylation of H3S10, and the bromodomain protein, Brd4, overview. P-TEFb accompanies the mature mRNA to the cytoplasm to promote translation elongation. Enzyme regulation system, detailed overview ADP + phosphoylated RNA polymerase II C-terminal subunit
-
 ?
additional information Saccharomyces cerevisiae P-TEFb co-operates with c-Myc during transactivation and cell transformation, and also requires SKIP, c-Ski-interacting protein, an mRNA elongationand splicing factor. Some functions of the P-TEFb/Ser2P CTD are executed by the Spt6 transcription elongation factor, which binds directly to the phosphorylated CTD and recruits the Iws1 protein, overview. Because P-TEFb counteracts NELF- and DSIF-induced pausing in cell-free transcription reactions, at least part of its activity does not depend upon chromatin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information budding yeast Saccharomyces cerevisiae
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RNA polymerase II C-terminal subunit the enzyme regulates transcription elongation at many genes and integrates mRNA synthesis with histone modification, pre-mRNA processing, and mRNA export. Recruitment of P-TEFb to target genes requires deubiquitination of H2Bub, phosphorylation of H3S10, and the bromodomain protein, Brd4, overview. P-TEFb accompanies the mature mRNA to the cytoplasm to promote translation elongation. Enzyme regulation system, detailed overview Saccharomyces cerevisiae ADP + phosphoylated RNA polymerase II C-terminal subunit
-
 ?
ATP + RNA polymerase II C-terminal subunit phosphorylation at Ser2, Ser5, and Ser7, the extended C-terminal domain, CTD, of the Rbp1 subunit contains 52 heptad repeats with a consensus sequence YSPTSPS Saccharomyces cerevisiae ADP + phosphoylated RNA polymerase II C-terminal subunit
-
 ?
additional information P-TEFb co-operates with c-Myc during transactivation and cell transformation, and also requires SKIP, c-Ski-interacting protein, an mRNA elongationand splicing factor. Some functions of the P-TEFb/Ser2P CTD are executed by the Spt6 transcription elongation factor, which binds directly to the phosphorylated CTD and recruits the Iws1 protein, overview. Because P-TEFb counteracts NELF- and DSIF-induced pausing in cell-free transcription reactions, at least part of its activity does not depend upon chromatin Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
CycT1:Cdk9
-
 Saccharomyces cerevisiae
P-TEFb
-
 Saccharomyces cerevisiae
RNA polymerase II Ser2 C-terminal domain kinase
-
 Saccharomyces cerevisiae
RNA polymerase II Ser2 CTD kinase
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Saccharomyces cerevisiae