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Literature summary for 2.7.11.23 extracted from

  • Xiao, T.; Shibata, Y.; Rao, B.; Laribee, R.N.; ORourke, R.; Buck, M.J.; Greenblatt, J.F.; Krogan, N.J.; Lieb, J.D.; Strahl, B.D.
    The RNA polymerase II kinase Ctk1 regulates positioning of a 5 histone methylation boundary along genes (2007), Mol. Cell. Biol., 27, 721-731.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.23

Application

Application Comment Organism
additional information Ctk1 controls the maintenance of suppressive chromatin in the coding regions of genes by both promoting H3K36 methylation, which leads to histone deacetylation, and preventing the 3' spread of H3K4 trimethylation, a mark associated with transcriptional initiation Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
D324N with catalytically dead allele of CTK1 Saccharomyces cerevisiae
additional information ctk1delta, CTK1 deletion, which nearly abolishes H3K4 monomethylation, but causes a significant increase in H3K4 di- and trimethylation, spread of H3K4 methylation in the ctk1delta strain is independent of Set2/K36 methylation, increased levels of cryptic initiation, RNA polymerase II elongation defects, or transcriptional stress Saccharomyces cerevisiae
additional information TK1 deletion nearly abolishes H3K4 monomethylation causing a significant increase in H3K4 di- and trimethylation. Both in individual genes and genome-wide, loss of CTK1 disrupts the H3K4 methylation patterns normally observed, H3K4me2 and H3K4me3 spread 3' into the bodies of genes, because H3K4 monomethylation is diminished, but restricted to the coding regions of RNAP II transcribed genes, overview Saccharomyces cerevisiae
T338A amino acid substitution that does not affect catalytic function Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
additional information Set1 is involved in disruption of the nucleosome at the 5' end, overview Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleosome
-
 Saccharomyces cerevisiae 786
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + RNA polymerase II C-terminal domain Saccharomyces cerevisiae Ctk1 kinase activity regulates H3K4 methylation, the Ctk2 and Ctk3 components of CTDK-1 are necessary for Ctk1 kinase activity, overview ADP + phosphoylated RNA polymerase II C-terminal subunit
-
 ?
ATP + RNA polymerase II C-terminal domain Saccharomyces cerevisiae BY4741 Ctk1 kinase activity regulates H3K4 methylation, the Ctk2 and Ctk3 components of CTDK-1 are necessary for Ctk1 kinase activity, overview ADP + phosphoylated RNA polymerase II C-terminal subunit
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae
-
 wild-type BY4741 strain
-
Saccharomyces cerevisiae BY4741
-
 wild-type BY4741 strain
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone H3 Ctk1 is essential for H3K36 methylation, also regulates H3K4 methylation Saccharomyces cerevisiae ?
-
 ?
ATP + histone H3 Ctk1 is essential for H3K36 methylation, also regulates H3K4 methylation Saccharomyces cerevisiae BY4741 ?
-
 ?
ATP + RNA polymerase II
-
 Saccharomyces cerevisiae ?
-
 ?
ATP + RNA polymerase II
-
 Saccharomyces cerevisiae BY4741 ?
-
 ?
ATP + RNA polymerase II C-terminal domain Ctk1 kinase activity regulates H3K4 methylation, the Ctk2 and Ctk3 components of CTDK-1 are necessary for Ctk1 kinase activity, overview Saccharomyces cerevisiae ADP + phosphoylated RNA polymerase II C-terminal subunit
-
 ?
ATP + RNA polymerase II C-terminal domain phosphorylation at Ser5, phosphorylation patterns, overview Saccharomyces cerevisiae ADP + phosphoylated RNA polymerase II C-terminal subunit
-
 ?
ATP + RNA polymerase II C-terminal domain Ctk1 kinase activity regulates H3K4 methylation, the Ctk2 and Ctk3 components of CTDK-1 are necessary for Ctk1 kinase activity, overview Saccharomyces cerevisiae BY4741 ADP + phosphoylated RNA polymerase II C-terminal subunit
-
 ?
ATP + RNA polymerase II C-terminal domain phosphorylation at Ser5, phosphorylation patterns, overview Saccharomyces cerevisiae BY4741 ADP + phosphoylated RNA polymerase II C-terminal subunit
-
 ?

Synonyms

Synonyms Comment Organism
C-terminal domain kinase
-
 Saccharomyces cerevisiae
CTD kinase
-
 Saccharomyces cerevisiae
Ctdk-1
-
 Saccharomyces cerevisiae
Ctk1
-
 Saccharomyces cerevisiae
Ctk1 kinase
-
 Saccharomyces cerevisiae
RNA polymerase II kinase
-
 Saccharomyces cerevisiae
serine 2 C-terminal domain kinase
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Saccharomyces cerevisiae