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Literature summary for 2.7.11.23 extracted from

  • Jacobs, E.Y.; Ogiwara, I.; Weiner, A.M.
    Role of the C-terminal domain of RNA polymerase II in U2 snRNA transcription and 3' processing (2004), Mol. Cell. Biol., 24, 846-855.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.23

Activating Compound

Activating Compound Comment Organism Structure
additional information UV irradiation and actinomycin D induce enzyme activity leading to inhibition of U2 snRNA transcription, inhibition by UV irrardiation can be rescued by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-(5-isoquinolinesulfonyl)-2-methylpiperazine i.e. H7, CTD kinase inhibitor, blocks mRNA elongation in vivo, but does not affect U2 snRNA transcription Homo sapiens
5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole CTD kinase inhibitor, blocks mRNA elongation in vivo, but does not affect U2 snRNA transcription Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [DNA-directed RNA polymerase] Homo sapiens the enzyme phosphorylates the C-terminal CTD domain of the RNA polymerase II large subunit, which has specific phosphorylation patterns for regulation of mRNA and snRNA processing ADP + phospho-[DNA-directed RNA polymerase]
-
 ?
additional information Homo sapiens the RNA polymerase II recruits factors including the enzyme that hyperphosphorylate its C-terminal domain, i.e. CTD, and the CTD in turn recruits proteins needed for mRNA splicing and polyadenylation, snRNA promoters probably recruit a CTD kinase, whose snRNA-specific phosphorylation patterns recruits factors required for promoter-coupled 3'-end formation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibrosarcoma cell
-
 Homo sapiens
-
HT-1080 cell fibrosarcoma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [DNA-directed RNA polymerase] the enzyme phosphorylates the C-terminal CTD domain of the RNA polymerase II large subunit, which has specific phosphorylation patterns for regulation of mRNA and snRNA processing Homo sapiens ADP + phospho-[DNA-directed RNA polymerase]
-
 ?
ATP + [DNA-directed RNA polymerase] the enzyme phosphorylates the C-terminal CTD domain of the RNA polymerase II large subunit Homo sapiens ADP + phospho-[DNA-directed RNA polymerase]
-
 ?
additional information the RNA polymerase II recruits factors including the enzyme that hyperphosphorylate its C-terminal domain, i.e. CTD, and the CTD in turn recruits proteins needed for mRNA splicing and polyadenylation, snRNA promoters probably recruit a CTD kinase, whose snRNA-specific phosphorylation patterns recruits factors required for promoter-coupled 3'-end formation, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CTD kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens