Literature summary for 2.7.11.23 extracted from

Kim, M.; Ahn, S.H.; Krogan, N.J.; Greenblatt, J.F.; Buratowski, S.
Transitions in RNA polymerase II elongation complexes at the 3' ends of genes (2004), EMBO J., 23, 354-364.

Search for more literature for 2.7.11.23

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	transcription through the polyadenylation site leads to a reduction in the levels of Ctk1 kinase protein and activity	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Saccharomyces cerevisiae	5634	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [DNA-directed RNA polymerase]	Saccharomyces cerevisiae	the enzyme is involved, together with several factors, in regulation of RNA elongation, transition at the 3' end, and polyadenylation, the enzyme is responsible for crosslinking of polyadenylation factors, overview	ADP + phospho-[DNA-directed RNA polymerase]	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [DNA-directed RNA polymerase]	the enzyme is involved, together with several factors, in regulation of RNA elongation, transition at the 3' end, and polyadenylation, the enzyme is responsible for crosslinking of polyadenylation factors, overview	Saccharomyces cerevisiae	ADP + phospho-[DNA-directed RNA polymerase]	-	?
ATP + [DNA-directed RNA polymerase]	Ctk1 kinase phosphorylates the C-terminal CTD domain of the RNA polymerase II large subunit, primarily at Ser2 and Ser5	Saccharomyces cerevisiae	ADP + phospho-[DNA-directed RNA polymerase]	-	?

Synonyms

Synonyms	Comment	Organism
Ctk1 kinase	-	Saccharomyces cerevisiae

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)