Activating Compound | Comment | Organism | Structure |
---|---|---|---|
p25 | required for activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ginsenoside F1 | noncompetitive inhibition | Homo sapiens | |
ginsenoside Rb1 | noncompetitive inhibition | Homo sapiens | |
ginsenoside Re | noncompetitive inhibition | Homo sapiens | |
ginsenoside Rf | noncompetitive inhibition | Homo sapiens | |
ginsenoside Rg1 | noncompetitive inhibition | Homo sapiens | |
ginsenoside Rg2 | noncompetitive inhibition | Homo sapiens | |
ginsenoside Rh1 | noncompetitive inhibition | Homo sapiens | |
additional information | ginsenosides as inhibitors of cyclin-dependent kinase 5/p25, structure-activity relationships, overview. Ginsenosides Rd, F2, Rb3, Rb2, Rg3, Rc, and Rh2 are no inhibitors of Cdk5/p25. No inhibition by protopanaxadiol | Homo sapiens | |
protopanaxatriol | noncompetitive inhibition | Homo sapiens | |
roscovitine | competitive inhibitor | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00285 | - |
PKTPKKAKKL | pH 7.5, 37°C | Homo sapiens | |
0.00522 | - |
ATP | pH 7.5, 37°C | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + PKTPKKAKKL | - |
Homo sapiens | ADP + PKpTPKKAKKL | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cdk5 | - |
Homo sapiens |
cyclin-dependent kinase 5 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | 37 | assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00025 | - |
pH 7.5, 37°C | Homo sapiens | roscovitine | |
0.00431 | - |
pH 7.5, 37°C | Homo sapiens | protopanaxatriol | |
0.0069 | - |
pH 7.5, 37°C | Homo sapiens | ginsenoside F1 | |
0.00728 | - |
pH 7.5, 37°C | Homo sapiens | ginsenoside Rh1 | |
0.00785 | - |
pH 7.5, 37°C | Homo sapiens | ginsenoside Rg1 | |
0.00901 | - |
pH 7.5, 37°C | Homo sapiens | ginsenoside Re | |
0.00976 | - |
pH 7.5, 37°C | Homo sapiens | ginsenoside Rf | |
0.0108 | - |
pH 7.5, 37°C | Homo sapiens | ginsenoside Rg2 | |
0.02496 | - |
pH 7.5, 37°C | Homo sapiens | ginsenoside Rb1 |
General Information | Comment | Organism |
---|---|---|
additional information | effect of ginsenosides on Alzheimer's disease may be involved with the regulation of activities of cdk5/p25. Enzyme activity measurement by mass spectrometry, UPLC/TQMS method development, usage with liquid chromatographic separation of product, overview | Homo sapiens |