Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cyclin T | CDK9 activating partner cyclin T1 | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | CDK9 represents a novel therapeutic target in chronic inflammatory diseases such as Rheumatoid Arthritis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
flavopiridol | a potent CDK9 inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + RNA polymerase II C-terminal domain protein | Homo sapiens | - |
ADP + RNA polymerase II C-terminal domain phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neutrophil | CDK 7 and CDK9 are the predominant CDKs present, with CDK5 present only at a very low level. CDK9 activity and the expression of its activating partner cyclin T1 both declined as neutrophils aged and entered apoptosis spontaneously. No cell cycle-dependent CDKs, CDK1, CDK2, CDK4 or CDK6, in neutrophils | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + RNA polymerase II C-terminal domain protein | - |
Homo sapiens | ADP + RNA polymerase II C-terminal domain phosphoprotein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CDK | - |
Homo sapiens |
Cdk5 | - |
Homo sapiens |
cdk7 | - |
Homo sapiens |
CDK9 | - |
Homo sapiens |
p27 cyclin dependent kinase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | inhibition of CDK9 with flavopiridol does not result in loss of Bcl2A | Homo sapiens |
physiological function | CDK9 is a component of the P-TEFb complex involved in transcriptional regulation. CDK9 activity is a key regulator of neutrophil lifespan, preventing apoptosis by maintaining levels of short lived anti-apoptotic proteins such as Mcl-1. Upon association with its activating partner cyclin T1, CDK9 forms P-TEFb, a general transcription factor responsible for phosphorylating the C-terminal domain of RNA polymerase II | Homo sapiens |